Interactive Osmolal Gap calculator. Requires the calculator gadget.
Usage: {{Osmolal Gap Calculator}}
Osmolal Gap
Serum Osmolal Gap
| Parameter
|
Value
|
| Measured Serum Osmolality (mOsm/kg)
|
|
| Sodium (Na⁺) mEq/L
|
|
| BUN (mg/dL)
|
|
| Glucose (mg/dL)
|
|
| Results
|
| Calculated Osmolality
|
mOsm/kg
|
| Osmolal Gap
|
mOsm/kg
|
| Interpretation
|
| <10
|
Normal — No significant unmeasured osmoles detected.
|
| >10
|
Elevated — Consider toxic alcohol ingestion: methanol, ethylene glycol, isopropanol, or other unmeasured osmoles (ethanol, mannitol, contrast dye).
|
| References
|
- Smithline N, Gardner KD Jr. Gaps—anionic and osmolal. JAMA. 1976;236(14):1594-1597. PMID 989116.
- Kraut JA, Xing SX. Approach to the evaluation of a patient with an increased serum osmolal gap and high-anion-gap metabolic acidosis. Am J Kidney Dis. 2011;58(3):480-484. PMID 21794966.
- Formula: Calculated Osm = 2(Na) + BUN/2.8 + Glucose/18. Gap = Measured − Calculated.
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