Template:Tetanus Antibiotics: Difference between revisions
(Convert to AntibioticDose with disease=Acute tetanus for SMW linking) |
(Add pediatric dosing) |
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====[[Penicillin]]==== | ====[[Penicillin]]==== | ||
*Although once the drug of choice it is now no longer recommended since it may potentiate the effect of tetanus toxin by inhibiting the GABA receptors<ref>Ganesh Kumar AV. Benzathine penicillin, metronidazole and benzyl penicillin in the treatment of tetanus: a randomized, controlled trial .Ann Trop Med Parasitol. 2004 Jan;98(1):59-63 PMID 15000732</ref> | *Although once the drug of choice it is now no longer recommended since it may potentiate the effect of tetanus toxin by inhibiting the GABA receptors<ref>Ganesh Kumar AV. Benzathine penicillin, metronidazole and benzyl penicillin in the treatment of tetanus: a randomized, controlled trial .Ann Trop Med Parasitol. 2004 Jan;98(1):59-63 PMID 15000732</ref> | ||
====Pediatric==== | |||
*{{AntibioticDose|disease=Acute tetanus|drug=Metronidazole|dose=7.5mg/kg IV q6hrs (max 500mg/dose) x 7-10 days|context=Pediatric Active tetanus|population=Pediatric}} '''OR''' | |||
*{{AntibioticDose|disease=Acute tetanus|drug=Clindamycin|dose=10-13mg/kg IV q8hrs (max 900mg/dose)|context=Pediatric Active tetanus alt|population=Pediatric}} | |||
Latest revision as of 13:09, 20 March 2026
- Metronidazole 500mg IV (7.5mg/kg) q6hrs OR
- Clindamycin 600mg IV (7.5mg/kg) q6hrs
Penicillin
- Although once the drug of choice it is now no longer recommended since it may potentiate the effect of tetanus toxin by inhibiting the GABA receptors[1]
Pediatric
- Metronidazole 7.5mg/kg IV q6hrs (max 500mg/dose) x 7-10 days OR
- Clindamycin 10-13mg/kg IV q8hrs (max 900mg/dose)
- ↑ Ganesh Kumar AV. Benzathine penicillin, metronidazole and benzyl penicillin in the treatment of tetanus: a randomized, controlled trial .Ann Trop Med Parasitol. 2004 Jan;98(1):59-63 PMID 15000732