Sodium zirconium cyclosilicate - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:57:32Z

Switch SMW query from broadtable to table format for better layout with TOC

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Danbot: Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

2026-03-20T17:26:44Z

Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

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Danbot: Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

2026-03-20T16:45:02Z

Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

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 *Available at Harbor-UCLA, but not yet widely available in the community
 *If asked by nephrology to give Kayexalate, kindly suggest Lokelma instead
 ==See Also==

Rossdonaldson1: /* Hyperkalemia */

2023-03-29T20:13:31Z

Hyperkalemia

← Older revision		Revision as of 20:13, 29 March 2023
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	==Adult Dosing==		==Adult Dosing==
	===Hyperkalemia===		===[[Hyperkalemia]]===
	*10 g TID PO for up to 48 hours, then 10 g once daily		*10 g TID PO for up to 48 hours, then 10 g once daily

Rossdonaldson1: /* Hyperkalemia */

2023-03-29T20:13:19Z

Hyperkalemia

← Older revision		Revision as of 20:13, 29 March 2023
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	==Adult Dosing==		==Adult Dosing==
	===Hyperkalemia===		===Hyperkalemia===
	10 g TID PO for up to 48 hours, then 10 g once daily		*10 g TID PO for up to 48 hours, then 10 g once daily

	==Pediatric Dosing==		==Pediatric Dosing==

Josgood: /* Mechanism of Action */

2023-03-24T06:15:30Z

Mechanism of Action

← Older revision		Revision as of 06:15, 24 March 2023
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	==Mechanism of Action==		==Mechanism of Action==
	*Highly selective, oral potassium removing agent		*Highly selective, oral potassium removing agent
	*Non-absorbed zirconium silicate that captures potassium in exchange ~~fro~~ hydrogen and sodium		*Non-absorbed zirconium silicate that captures potassium in exchange for hydrogen and sodium
	*Increases fecal potassium excretion through binding K+ in GI tract		*Increases fecal potassium excretion through binding K+ in GI tract

Gpowellhb: /* Comments */

2020-02-12T23:44:23Z

Comments

← Older revision		Revision as of 23:44, 12 February 2020
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	*Onset of action at 1.0 hour and median time to achieving normal potassium levels at 2.2 hours, with 92% achieving normal potassium within 48 hours.		*Onset of action at 1.0 hour and median time to achieving normal potassium levels at 2.2 hours, with 92% achieving normal potassium within 48 hours.
	*Not used as an emergency treatment for life threatening hyperkalemia due to delayed onset of action		*Not used as an emergency treatment for life threatening hyperkalemia due to delayed onset of action
			*Available at Harbor-UCLA, but not yet widely available in the community
			*If asked by nephrology to give Kayexalate, kindly suggest Lokelma instead

	==See Also==		==See Also==

ClaireLewis at 22:30, 23 September 2019

2019-09-23T22:30:22Z

← Older revision		Revision as of 22:30, 23 September 2019
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	==Administration<ref>Packham, D. K., Rasmussen, H. S., Lavin, P. T., El-Shahawy, M. A., Roger, S. D., Block, G., … Singh, B. (2015). Sodium zirconium cyclosilicate in hyperkalemia. The New England Journal of Medicine, 372(3), 222–231.</ref>==		==Administration<ref>Packham, D. K., Rasmussen, H. S., Lavin, P. T., El-Shahawy, M. A., Roger, S. D., Block, G., … Singh, B. (2015). Sodium zirconium cyclosilicate in hyperkalemia. The New England Journal of Medicine, 372(3), 222–231.</ref>==
	*Type: Potassium binder, antidote		*Type: Potassium binder, [[antidote]]
	*Dosage Forms: 5 g (1 ea, 30 ea); 10 g (1 ea, 30 ea), empty contents into glass with 45 mL of water		*Dosage Forms: 5 g (1 ea, 30 ea); 10 g (1 ea, 30 ea), empty contents into glass with 45 mL of water
	*Routes of Administration: Oral		*Routes of Administration: Oral
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	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:FEN]]

Mrosen5506: Created page with "==AdministrationPackham, D. K., Rasmussen, H. S., Lavin, P. T., El-Shahawy, M. A., Roger, S. D., Block, G., … Singh, B. (2015). Sodium zirconium cyclosilicate in hyperk..."

2018-08-12T18:09:46Z

Created page with "==Administration<ref>Packham, D. K., Rasmussen, H. S., Lavin, P. T., El-Shahawy, M. A., Roger, S. D., Block, G., … Singh, B. (2015). Sodium zirconium cyclosilicate in hyperk..."

New page

==Administration<ref>Packham, D. K., Rasmussen, H. S., Lavin, P. T., El-Shahawy, M. A., Roger, S. D., Block, G., … Singh, B. (2015). Sodium zirconium cyclosilicate in hyperkalemia. The New England Journal of Medicine, 372(3), 222–231.</ref>==
*Type: Potassium binder, antidote
*Dosage Forms: 5 g (1 ea, 30 ea); 10 g (1 ea, 30 ea), empty contents into glass with 45 mL of water
*Routes of Administration: Oral
*Common Trade Names: Lokelma

==Adult Dosing==
===Hyperkalemia===
10 g TID PO for up to 48 hours, then 10 g once daily

==Pediatric Dosing==

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*unlikely to affect fetus as not absorbed

===Lactation risk===
*unlikely to be in breast milk as not absorbed

===Renal Dosing===
None

===Hepatic Dosing===
None

==Contraindications==
*Allergy to class/drug
*Avoid in GI motility disorders

==Adverse Reactions==
===Serious===

===Common===
*Mild to moderate edema
*Hypokalemia

==Pharmacology==
*Metabolism: none
*Excretion: feces

==Mechanism of Action==
*Highly selective, oral potassium removing agent
*Non-absorbed zirconium silicate that captures potassium in exchange fro hydrogen and sodium
*Increases fecal potassium excretion through binding K+ in GI tract

==Comments==
*Onset of action at 1.0 hour and median time to achieving normal potassium levels at 2.2 hours, with 92% achieving normal potassium within 48 hours.
*Not used as an emergency treatment for life threatening hyperkalemia due to delayed onset of action

==See Also==
[[Hyperkalemia]]

==References==
<references/>

[[Category:Pharmacology]]