Neostigmine - Revision history

SeanDenny: /* See Also */

2020-12-15T00:32:24Z

ClaireLewis: /* Special Populations */

2019-09-22T23:48:09Z

Special Populations

← Older revision		Revision as of 23:48, 22 September 2019
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	*Safety/efficacy not well-established in peds, but generally same weight-based dosing as adults		*Safety/efficacy not well-established in peds, but generally same weight-based dosing as adults
	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: Fetal risk cannot be ruled out		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C, Fetal risk cannot be ruled out
	*[[Lactation risk categories\|Lactation risk]]: Avoid breastfeeding		*[[Lactation risk categories\|Lactation risk]]: Avoid breastfeeding
	*Renal dosing: no adjustment		*Renal dosing: no adjustment

Mholtz: Text replacement - "-->" to "→"

2017-02-08T20:58:45Z

Text replacement - "-->" to "→"

← Older revision		Revision as of 20:58, 8 February 2017
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	==Mechanism of Action==		==Mechanism of Action==
	*Competitive cholinesterase ~~inhibitor-->~~ less breakdown of ~~acetylcholine-->~~ more acetylcholine in synapses		*Competitive cholinesterase inhibitor→ less breakdown of acetylcholine→ more acetylcholine in synapses

	==Comments==		==Comments==

ClaireLewis at 15:39, 5 September 2016

2016-09-05T15:39:14Z

← Older revision		Revision as of 15:39, 5 September 2016
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	==Administration==		==Administration==
	*Type:		*Type: Cholinesterase inhibitor
	*Dosage Forms:		*Dosage Forms:
	*Routes of Administration:		*Routes of Administration: IV, oral (not FDA-approved)
	*Common Trade Names:		*Common Trade Names:

	==Adult Dosing==		==Adult Dosing==
			*Reversal of non-depolarizing [[neuromuscular blocking agents]]:
			**Initial: 0.03-0.07 mg/kg IV, if no efffect, repeat q1 min up to max total dose of 0.07mg/kg or 5mg
			*[[Myasthenia gravis]]: 15-375mg PO daily (Not FDA-approved)

	==Pediatric Dosing==		==Pediatric Dosing==
			*Safety/efficacy not well-established in peds, but generally same weight-based dosing as adults
	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]:		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: Fetal risk cannot be ruled out
	*[[Lactation risk categories\|Lactation risk]]:		*[[Lactation risk categories\|Lactation risk]]: Avoid breastfeeding
	~~===~~Renal ~~Dosing===~~		*Renal dosing: no adjustment
	*Adult:		*Hepatic dosing: no adjustment
	*~~Pediatric:~~
	~~===~~Hepatic ~~Dosing===~~
	*Adult:
	*Pediatric:

	==Contraindications==		==Contraindications==
	*Allergy to class/drug		*Allergy to class/drug
			*Mechanical bowel or urinary tract obstruction
			*Peritonitis

	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
			*Bradyarrythmia, Atrioventricular block
			*Seizure, loss of conciousness
	===Common===		===Common===
			*Hypotension
			*Nausea, vomiting

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 40-75 min
	*Metabolism:		*Metabolism: Hepatic (extensive)
	*Excretion:		*Excretion: Renal

	==Mechanism of Action==		==Mechanism of Action==
			*Competitive cholinesterase inhibitor--> less breakdown of acetylcholine--> more acetylcholine in synapses

	==Comments==		==Comments==

	==See Also==		==See Also==
			*[[Neuromuscular blocking agents]]
			*[[Myaesthenia gravis]]
			*[[Pyridostigmine]]
	==References==		==References==
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]

ClaireLewis: Created page with "==Administration== Type: Dosage Forms: Routes of Administration: Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== *Drug Ratings in..."

2016-09-05T15:17:18Z

Created page with "==Administration== *Type: *Dosage Forms: *Routes of Administration: *Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== *Drug Ratings in..."

New page

==Administration==
*Type:
*Dosage Forms:
*Routes of Administration:
*Common Trade Names:

==Adult Dosing==

==Pediatric Dosing==

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
*[[Lactation risk categories|Lactation risk]]:
===Renal Dosing===
*Adult:
*Pediatric:
===Hepatic Dosing===
*Adult:
*Pediatric:

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===

===Common===

==Pharmacology==
*Half-life:
*Metabolism:
*Excretion:

==Mechanism of Action==

==Comments==

==See Also==

==References==
<references/>
[[Category:Pharmacology]]