Myelofibrosis - Revision history

ClaireLewis at 04:56, 1 October 2019

2019-10-01T04:56:58Z

← Older revision		Revision as of 04:56, 1 October 2019
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	==Background==		==Background==
	*Chronic myeloproliferative disorder		*Chronic [[myeloproliferative disorders\|myeloproliferative disorder]]
	*Abnormal proliferation is seen in all 3 cell lines		*Abnormal proliferation is seen in all 3 cell lines
	*Typically in elderly		*Typically in elderly
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	==Differential Diagnosis==		==Differential Diagnosis==
	*[[Polycythemia vera]] (PV)		*[[Polycythemia vera]] (PV)
	*Essential thrombocytosis (ET)		*[[Essential thrombocytosis]] (ET)
	*[[Chronic myelogenous leukemia]] (CML)		*[[Chronic myelogenous leukemia]] (CML)
	*[[Leukemoid Reaction]]		*[[Leukemoid Reaction]]
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	===Diagnosis<ref>Tefferi, A, et al. The 2008 World Health Organization classification system for myeloproliferative neoplasms: order out of chaos. Cancer. 2009; 115(17):3842-7,</ref>===		===Diagnosis<ref>Tefferi, A, et al. The 2008 World Health Organization classification system for myeloproliferative neoplasms: order out of chaos. Cancer. 2009; 115(17):3842-7,</ref>===
	*Anemia		*[[Anemia]]
	*Pancytopenia (in late disease)		*[[Pancytopenia]] (in late disease)
	*Increased serum LDH		*Increased serum LDH

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	==Management==		==Management==
	*Blood transfusion		*[[Blood transfusion]]
	*Ruxolitinib		*Ruxolitinib
	*Allogeneic stem cell transplantation		*Allogeneic stem cell transplantation

ClaireLewis: /* Differential Diagnosis */

2019-08-15T18:40:26Z

Differential Diagnosis

← Older revision		Revision as of 18:40, 15 August 2019
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	*Essential thrombocytosis (ET)		*Essential thrombocytosis (ET)
	*[[Chronic myelogenous leukemia]] (CML)		*[[Chronic myelogenous leukemia]] (CML)
	*Leukemoid ~~reactions~~		*[[Leukemoid Reaction]]

	==Evaluation==		==Evaluation==

Rossdonaldson1 at 20:23, 20 March 2017

2017-03-20T20:23:50Z

← Older revision		Revision as of 20:23, 20 March 2017
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	==Clinical Features==		==Clinical Features==
	**Anemia		*Palpable splenomegaly
	**Pancytopenia (in late disease)		*Bone pain
	**Palpable splenomegaly
	**Bone pain
	**Increased serum LDH

	==Differential Diagnosis==		==Differential Diagnosis==
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	*[[Chronic myelogenous leukemia]] (CML)		*[[Chronic myelogenous leukemia]] (CML)
	*Leukemoid reactions		*Leukemoid reactions


	==Evaluation==		==Evaluation==
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	*Bone marrow biopsy		*Bone marrow biopsy

	===~~Evaluation~~<ref>Tefferi, A, et al. The 2008 World Health Organization classification system for myeloproliferative neoplasms: order out of chaos. Cancer. 2009; 115(17):3842-7,</ref>===		===Diagnosis<ref>Tefferi, A, et al. The 2008 World Health Organization classification system for myeloproliferative neoplasms: order out of chaos. Cancer. 2009; 115(17):3842-7,</ref>===
			*Anemia
			*Pancytopenia (in late disease)
			*Increased serum LDH

	*Criteria: The diagnosis of primary myelofibrosis requires meeting all 3 major criteria and 2 minor criteria.		*Criteria: The diagnosis of primary myelofibrosis requires meeting all 3 major criteria and 2 minor criteria.

Unenthusiastic: /* Background */

2017-03-15T23:13:05Z

Background

← Older revision		Revision as of 23:13, 15 March 2017
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	*Typically in elderly		*Typically in elderly
	*Can be asymptomatic or symptomatic		*Can be asymptomatic or symptomatic
			*Can be primary or develop secondary to [[polycythemia vera]] or [[essential thrombocytosis]]

	==Clinical Features==		==Clinical Features==

Unenthusiastic: /* EvaluationTefferi, A, et al. The 2008 World Health Organization classification system for myeloproliferative neoplasms: order out of chaos. Cancer. 2009; 115(17):3842-7, */

2017-03-15T23:10:00Z

EvaluationTefferi, A, et al. The 2008 World Health Organization classification system for myeloproliferative neoplasms: order out of chaos. Cancer. 2009; 115(17):3842-7,

← Older revision		Revision as of 23:10, 15 March 2017
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	===Evaluation<ref>Tefferi, A, et al. The 2008 World Health Organization classification system for myeloproliferative neoplasms: order out of chaos. Cancer. 2009; 115(17):3842-7,</ref>===		===Evaluation<ref>Tefferi, A, et al. The 2008 World Health Organization classification system for myeloproliferative neoplasms: order out of chaos. Cancer. 2009; 115(17):3842-7,</ref>===
	*Criteria: The diagnosis of ~~PMF~~ requires meeting all 3 major criteria and 2 minor criteria.		*Criteria: The diagnosis of primary myelofibrosis requires meeting all 3 major criteria and 2 minor criteria.

	{\| class="wikitable"		{\| class="wikitable"

Unenthusiastic: Created page with "==Background== Chronic myeloproliferative disorder Abnormal proliferation is seen in all 3 cell lines Typically in elderly Can be asymptomatic or symptomatic ==Clinical F..."

2017-03-15T23:08:54Z

Created page with "==Background== *Chronic myeloproliferative disorder *Abnormal proliferation is seen in all 3 cell lines *Typically in elderly *Can be asymptomatic or symptomatic ==Clinical F..."

New page

==Background==
*Chronic myeloproliferative disorder
*Abnormal proliferation is seen in all 3 cell lines
*Typically in elderly
*Can be asymptomatic or symptomatic

==Clinical Features==
**Anemia
**Pancytopenia (in late disease)
**Palpable splenomegaly
**Bone pain
**Increased serum LDH

==Differential Diagnosis==
*[[Polycythemia vera]] (PV)
*Essential thrombocytosis (ET)
*[[Chronic myelogenous leukemia]] (CML)
*Leukemoid reactions

==Evaluation==
===Workup===
*CBC
*Blood smear
*Chem 7
*Bone marrow biopsy

===Evaluation<ref>Tefferi, A, et al. The 2008 World Health Organization classification system for myeloproliferative neoplasms: order out of chaos. Cancer. 2009; 115(17):3842-7,</ref>===
*Criteria: The diagnosis of PMF requires meeting all 3 major criteria and 2 minor criteria.

{| class="wikitable"
|-
! Major criteria
|-
| Megakaryocyte proliferation and atypia with reticulin and/or collagen fibrosis,
or with increased marrow cellularity, granulocytic proliferation, and decreased erythropoiesis
|-
| Not meeting WHO criteria for CML, PV, MDS, or other myeloid neoplasm
|-
| Demonstration of JAK2V617F or other clonal marker or no evidence of reactive bone marrow fibrosis
|}

{| class="wikitable"
|-
! Minor criteria
|-
| Leukoerythroblastosis
|-
| Increased serum LDH
|-
| Anemia
|-
| Palpable splenomegaly
|}

==Management==
*Blood transfusion
*Ruxolitinib
*Allogeneic stem cell transplantation

==Also See==

==References==
<references/>

[[Category:Heme/Onc]]