Leukemoid reaction - Revision history

Danbot: Danbot moved page Leukemoid Reaction to Leukemoid reaction without leaving a redirect: Naming convention: first word capitalized, subsequent words lowercase

2026-03-22T05:31:43Z

Danbot moved page Leukemoid Reaction to Leukemoid reaction without leaving a redirect: Naming convention: first word capitalized, subsequent words lowercase

← Older revision	Revision as of 05:31, 22 March 2026
(No difference)

Rossdonaldson1: /* Literature Review */

2023-01-11T21:47:20Z

Literature Review

← Older revision		Revision as of 21:47, 11 January 2023
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	* Cutoff is variable, 25-50k<ref>Sakka V, Tsiodras S, Giamarellos-Bourboulis EJ, Giamarellou H. An update on the etiology and diagnostic evaluation of a leukemoid reaction. Eur J Intern Med. 2006;17(6):394-398. doi:10.1016/j.ejim.2006.04.004.</ref>		* Cutoff is variable, 25-50k<ref>Sakka V, Tsiodras S, Giamarellos-Bourboulis EJ, Giamarellou H. An update on the etiology and diagnostic evaluation of a leukemoid reaction. Eur J Intern Med. 2006;17(6):394-398. doi:10.1016/j.ejim.2006.04.004.</ref>

	==Literature Review==		===Literature Review===
	=== Retrospective review of 135 patients with WBC >25k <ref>Reding MT, Hibbs JR, Morrison VA, Swaim WR, Filice GA. Diagnosis and outcome of 100 consecutive patients with extreme granulocytic leukocytosis. Am J Med. 1998;104(1):12-16.</ref> ===		==== Retrospective review of 135 patients with WBC >25k <ref>Reding MT, Hibbs JR, Morrison VA, Swaim WR, Filice GA. Diagnosis and outcome of 100 consecutive patients with extreme granulocytic leukocytosis. Am J Med. 1998;104(1):12-16.</ref> ====
	* 48% infection		* 48% infection
	* 15% malignancy		* 15% malignancy
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	* 12% glucocorticoid or granulocyte colony stimulating therapy		* 12% glucocorticoid or granulocyte colony stimulating therapy

	=== Retrospective review of 173 patients with WBC >30k <ref>Potasman I, Grupper M. Leukemoid reaction: spectrum and prognosis of 173 adult patients. Clin Infect Dis. 2013;57(11):e177-e181. doi:10.1093/cid/cit562.</ref> ===		==== Retrospective review of 173 patients with WBC >30k <ref>Potasman I, Grupper M. Leukemoid reaction: spectrum and prognosis of 173 adult patients. Clin Infect Dis. 2013;57(11):e177-e181. doi:10.1093/cid/cit562.</ref> ====
	* 48% infection (7% C. difficile)		* 48% infection (7% C. difficile)
	* 28% tissue ischemia		* 28% tissue ischemia
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	* 5% malignancy		* 5% malignancy

	=== Observational study of 54 patients with WBC >25k <ref>Lawrence YR, Raveh D, Rudensky B, Munter G. Extreme leukocytosis in the emergency department. QJM. 2007;100(4):217-223. doi:10.1093/qjmed/hcm006.</ref> ===		==== Observational study of 54 patients with WBC >25k <ref>Lawrence YR, Raveh D, Rudensky B, Munter G. Extreme leukocytosis in the emergency department. QJM. 2007;100(4):217-223. doi:10.1093/qjmed/hcm006.</ref> ====
	* Consecutive patients presenting to the emergency department		* Consecutive patients presenting to the emergency department
	* Compared to age-matched controls with moderate leukocytosis (12-24k)		* Compared to age-matched controls with moderate leukocytosis (12-24k)

ClaireLewis: /* Background */

2019-10-01T04:43:06Z

Background

← Older revision		Revision as of 04:43, 1 October 2019
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	==Background==		==Background==
	* Markedly elevated leukocyte (particularly neutrophil) count without hematologic malignancy		* Markedly [[leukocytosis\|elevated leukocyte]] (particularly neutrophil) count without hematologic malignancy
	* Cutoff is variable, 25-50k<ref>Sakka V, Tsiodras S, Giamarellos-Bourboulis EJ, Giamarellou H. An update on the etiology and diagnostic evaluation of a leukemoid reaction. Eur J Intern Med. 2006;17(6):394-398. doi:10.1016/j.ejim.2006.04.004.</ref>		* Cutoff is variable, 25-50k<ref>Sakka V, Tsiodras S, Giamarellos-Bourboulis EJ, Giamarellou H. An update on the etiology and diagnostic evaluation of a leukemoid reaction. Eur J Intern Med. 2006;17(6):394-398. doi:10.1016/j.ejim.2006.04.004.</ref>

ClaireLewis at 18:26, 15 August 2019

2019-08-15T18:26:49Z

← Older revision		Revision as of 18:26, 15 August 2019
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	==Clinical Features==		==Clinical Features==
			*Signs/symptoms of underlying pathology or asymptomatic

	==Differential Diagnosis==		==Differential Diagnosis==
			*Infection
			**Any severe infection
			**Particularly [[c. diff]], [[TB]], [[shigella]]
			*Drugs/tox
			**[[Corticosteroids]]
			**G-CSF
			**[[Ethylene glycol]]
			*Tissue ischemia
			**[[Myocardial infarction]]
			**[[Mesenteric ischemia]]
			**[[Gangrene]]
			*Malignancy, [[paraneoplastic]]
	[[File:Leukemoid Reaction.png\|Differential Diagnosis of Leukemoid Reaction]]		[[File:Leukemoid Reaction.png\|Differential Diagnosis of Leukemoid Reaction]]

	==Management==		==Management==
			*Treat underlying condition

	==Disposition==		==Disposition==

Mholtz at 01:21, 16 September 2018

2018-09-16T01:21:51Z

← Older revision		Revision as of 01:21, 16 September 2018
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	* Compared to age-matched controls with moderate leukocytosis (12-24k)		* Compared to age-matched controls with moderate leukocytosis (12-24k)
	* Patients with leukemoid reaction were more likely to have an infection, be hospitalized and die.		* Patients with leukemoid reaction were more likely to have an infection, be hospitalized and die.

			==Clinical Features==


	==Differential Diagnosis==		==Differential Diagnosis==
	[[File:Leukemoid Reaction.png\|Differential Diagnosis of Leukemoid Reaction]]		[[File:Leukemoid Reaction.png\|Differential Diagnosis of Leukemoid Reaction]]

			==Management==


			==Disposition==


	==External Links==		==External Links==
	* [https://ddxof.com/leukemoid-reaction/ Leukemoid Reaction on ddxof]		*[https://ddxof.com/leukemoid-reaction/ Leukemoid Reaction on ddxof]

	==References==		==References==
	<references/>		<references/>

			[[Category:Heme/Onc]]

Tomfadial: New page

2018-09-08T17:38:30Z

New page

New page

==Background==
* Markedly elevated leukocyte (particularly neutrophil) count without hematologic malignancy
* Cutoff is variable, 25-50k<ref>Sakka V, Tsiodras S, Giamarellos-Bourboulis EJ, Giamarellou H. An update on the etiology and diagnostic evaluation of a leukemoid reaction. Eur J Intern Med. 2006;17(6):394-398. doi:10.1016/j.ejim.2006.04.004.</ref>

==Literature Review==
=== Retrospective review of 135 patients with WBC >25k <ref>Reding MT, Hibbs JR, Morrison VA, Swaim WR, Filice GA. Diagnosis and outcome of 100 consecutive patients with extreme granulocytic leukocytosis. Am J Med. 1998;104(1):12-16.</ref> ===
* 48% infection
* 15% malignancy
* 9% hemorrhage
* 12% glucocorticoid or granulocyte colony stimulating therapy

=== Retrospective review of 173 patients with WBC >30k <ref>Potasman I, Grupper M. Leukemoid reaction: spectrum and prognosis of 173 adult patients. Clin Infect Dis. 2013;57(11):e177-e181. doi:10.1093/cid/cit562.</ref> ===
* 48% infection (7% C. difficile)
* 28% tissue ischemia
* 7% obstetric process (vaginal or cesarean delivery)
* 5% malignancy

=== Observational study of 54 patients with WBC >25k <ref>Lawrence YR, Raveh D, Rudensky B, Munter G. Extreme leukocytosis in the emergency department. QJM. 2007;100(4):217-223. doi:10.1093/qjmed/hcm006.</ref> ===
* Consecutive patients presenting to the emergency department
* Compared to age-matched controls with moderate leukocytosis (12-24k)
* Patients with leukemoid reaction were more likely to have an infection, be hospitalized and die.

==Differential Diagnosis==
[[File:Leukemoid Reaction.png|Differential Diagnosis of Leukemoid Reaction]]

==External Links==
* [https://ddxof.com/leukemoid-reaction/ Leukemoid Reaction on ddxof]

==References==
<references/>