Intralipid - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:56:41Z

Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T17:25:59Z

Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

2026-03-20T16:44:09Z

Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

@@ Line 91: / Line 91: @@
 **High-dose [[epinephrine]]
 **[[Propofol]]
 ==See Also==

2024-04-17T20:18:28Z

Comments

← Older revision		Revision as of 20:18, 17 April 2024
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	==Comments==		==Comments==
	*Avoid co-administration of:<ref>http://www.lipidrescue.org/</ref>		*Avoid co-administration of:<ref>http://www.lipidrescue.org/</ref>
	**Vasopressin		**[[Vasopressin]]
	**Calcium channel blockers		**[[Calcium channel blockers]]
	**Beta-blockers		**[[Beta-blockers]]
	**Local anesthetics		**[[Local anesthetics]]
	**High-dose epinephrine		**High-dose [[epinephrine]]
	**Propofol		**[[Propofol]]

	==See Also==		==See Also==

2024-04-16T22:16:08Z

Persistent Cardiovascular Collapse

← Older revision		Revision as of 22:16, 16 April 2024
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	*May repeat bolus once or twice for persistent cardiovascular collapse<ref>http://www.lipidrescue.org/</ref>		*May repeat bolus once or twice for persistent cardiovascular collapse<ref>http://www.lipidrescue.org/</ref>
	*May double rate of infusion to 0.5 mL/kg/min for persistent hypotension<ref>http://www.lipidrescue.org/</ref>		*May double rate of infusion to 0.5 mL/kg/min for persistent hypotension<ref>http://www.lipidrescue.org/</ref>
			*Max cumulative dose: 12 ml/kg

	===After Cardiovascular Stability Achieved===		===After Cardiovascular Stability Achieved===

2019-05-15T19:13:01Z

Comments

← Older revision		Revision as of 19:13, 15 May 2019
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	==Comments==		==Comments==
	*Avoid co-administration of<ref>http://www.lipidrescue.org/</ref>		*Avoid co-administration of:<ref>http://www.lipidrescue.org/</ref>
	**Vasopressin		**Vasopressin
	**Calcium channel blockers		**Calcium channel blockers

2019-05-15T19:12:39Z

Comments

← Older revision		Revision as of 19:12, 15 May 2019
Line 83:		Line 83:

	==Comments==		==Comments==
			*Avoid co-administration of<ref>http://www.lipidrescue.org/</ref>
			**Vasopressin
			**Calcium channel blockers
			**Beta-blockers
			**Local anesthetics
			**High-dose epinephrine
			**Propofol

	==See Also==		==See Also==

2019-05-15T19:11:26Z

Pharmacology

← Older revision		Revision as of 19:11, 15 May 2019
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	*Excretion:		*Excretion:
	*Mechanism of Action:		*Mechanism of Action:
	**Emulsion ~~acts as a “lipid sink,” surrounding a~~ lipophilic drug molecule ~~and rendering~~ it ~~ineffective~~		**Unclear, but proposed mechanisms include<ref>https://canadiem.org/iv-lipid-emulsion-for-drug-toxicity-in-the-ed/</ref>:
	**Fatty acids ~~from the ILE~~ provide the myocardium with a ready energy source, improving cardiac ~~function~~		***Lipid sink/partition
			****Emulsion surrounds lipophilic drug molecule, partitioning it from target organs
			***Cardiac metabolism
			****Fatty acids provide the myocardium with a ready energy source, improving cardiac contractility

	==Comments==		==Comments==

2019-05-15T19:08:46Z

Serious

← Older revision		Revision as of 19:08, 15 May 2019
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	*Fat embolism		*Fat embolism
	*Hypersensitivity reactions		*Hypersensitivity reactions
			*ARDS

	===Common===		===Common===

2019-05-15T19:07:32Z

Emergency department indications

← Older revision		Revision as of 19:07, 15 May 2019
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	**Pediatric		**Pediatric

	==Emergency department indications==		==Emergency department indications<ref>http://www.lipidrescue.org/</ref><ref>https://canadiem.org/iv-lipid-emulsion-for-drug-toxicity-in-the-ed/</ref>==
	*[[Local anesthetic systemic toxicity]]		*Severe systemic drug toxicity plus:
	*Refractory hemodynamic instability secondary to ingestion of cardiodepressive medications / toxins		**Persistent hemodynamic instability
			**All conventional options have been exhausted
			**Toxicity has poor prognosis
			*Common toxicities
			**[[Local anesthetic systemic toxicity]]
	**[[Beta blocker]]		**[[Beta blocker]]
	**[[Calcium Channel Blocker]]		**[[Calcium Channel Blocker]]