Alvarez13 at 05:26, 27 November 2016

2016-11-27T05:26:02Z

← Older revision		Revision as of 05:26, 27 November 2016
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	*Malaria prophylaxis: 400 mg PO weekly beginning 1 to 2 weeks prior to travel to malarious area through 4 weeks after departure		*Malaria prophylaxis: 400 mg PO weekly beginning 1 to 2 weeks prior to travel to malarious area through 4 weeks after departure
	===Other indications===		===Other indications===
	*Lupus: 200-400mg PO 1-2 times per day		*[[Lupus]]: 200-400mg PO 1-2 times per day
	*Rheumatoid ~~arthritis~~: 200-600mg PO daily		*[[Rheumatoid Arthritis]]: 200-600mg PO daily

	==Pediatric Dosing==		==Pediatric Dosing==

ClaireLewis: /* See Also */

2016-11-13T02:08:54Z

ClaireLewis: Created page with "==Administration== Type: Antimalarial, anti-inflammatory Dosage Forms: Routes of Administration: Oral Common Trade Names: Plaquenil ==Adult Dosing== ===Malaria=== ''M..."

2016-11-13T02:08:32Z

Created page with "==Administration== *Type: Antimalarial, anti-inflammatory *Dosage Forms: *Routes of Administration: Oral *Common Trade Names: Plaquenil ==Adult Dosing== ===Malaria=== ''M..."

New page

==Administration==
*Type: [[Antimalarial]], anti-inflammatory
*Dosage Forms:
*Routes of Administration: Oral
*Common Trade Names: Plaquenil

==Adult Dosing==
===Malaria===
''Most malaria-endemic areas have high rates of chloroquine resistance. Per the CDC, chloroquine-sensitive areas include: Central America west of the Panama Canal, Haiti, the Dominican Republic, and most of the Middle East. See [[https://www.cdc.gov/malaria/travelers/country_table/a.html CDC malaria information by country]] for details''
*Malaria treatment: 800 mg PO, then 400 mg PO at 6, 24, and 48 hours after initial dose
*Malaria prophylaxis: 400 mg PO weekly beginning 1 to 2 weeks prior to travel to malarious area through 4 weeks after departure
===Other indications===
*Lupus: 200-400mg PO 1-2 times per day
*Rheumatoid arthritis: 200-600mg PO daily

==Pediatric Dosing==
*Malaria treatment: 12.9 mg/kg (max 800mg) PO, then 6.45 mg/kg PO at 6, 24, and 48 hours after initial dose
*Malaria prophylaxis: 6.45 mg/kg PO weekly beginning 1 to 2 weeks prior to travel to malarious area through 4 weeks after departure

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: D
*[[Lactation risk categories|Lactation risk]]: Infant risk minimal
*Renal dosing:
*Hepatic dosing:

==Contraindications==
*Allergy to class/drug
*Retinal or visual field changes from prior 4-aminoquinoline compound
*Prolonged use in children

==Adverse Reactions==
===Serious===
*Torsades de pointes
*Agranulocytosis, leukopenia, thrombocytopenia, aplastic anemia
*Fulminant hepatic failure
*Myopathy
*Seizure
*Retinopathy
*Hearing loss
*Angioedema
===Common===
*Corneal disorder

==Pharmacology==
*Half-life: 7-50 days
*Metabolism: Hepatic
*Excretion: Mostly renal

==Mechanism of Action==
*Precise mechanism unknown

==Comments==

==See Also==

==References==
<references/>
[[Category:Pharmacology]]

← Older revision		Revision as of 02:08, 13 November 2016
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	==See Also==		==See Also==
			*[[Antimalarial medications]]
			*[[Malaria]]

	==References==		==References==
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Hydroxychloroquine - Revision history

Alvarez13 at 05:26, 27 November 2016

ClaireLewis: /* See Also */

ClaireLewis: Created page with "==Administration== *Type: Antimalarial, anti-inflammatory *Dosage Forms: *Routes of Administration: Oral *Common Trade Names: Plaquenil ==Adult Dosing== ===Malaria=== ''M..."

ClaireLewis: Created page with "==Administration== Type: Antimalarial, anti-inflammatory Dosage Forms: Routes of Administration: Oral Common Trade Names: Plaquenil ==Adult Dosing== ===Malaria=== ''M..."