https://wikem.org/w/index.php?action=history&feed=atom&title=Glucarpidase 2026-04-19T22:11:19Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Glucarpidase&diff=229414&oldid=prev 2019-09-22T20:14:43Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 20:14, 22 September 2019</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Administration==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Administration==</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*Type: [[antidote]]</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Dosage Forms: 1000 units/vial</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Dosage Forms: 1000 units/vial</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Routes of Administration: IV</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Routes of Administration: IV</div></td></tr> <tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l55">Line 55:</td> <td colspan="2" class="diff-lineno">Line 56:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pharmacology]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pharmacology]]</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Toxicology]]</ins></div></td></tr> </table>

ClaireLewis https://wikem.org/w/index.php?title=Glucarpidase&diff=118512&oldid=prev 2017-01-12T22:36:18Z

<p>Creation of page</p> <p><b>New page</b></p><div>==Administration==<br /> *Dosage Forms: 1000 units/vial<br /> *Routes of Administration: IV<br /> *Common Trade Names: Voraxaze<br /> <br /> ==Adult Dosing==<br /> *[[Methotrexate toxicity]]<br /> **50 units/kg IV x1<br /> ***For patients with mod-severe renal impairment<br /> <br /> ==Pediatric Dosing==<br /> *[[Methotrexate toxicity]]<br /> **50 units/kg IV x1<br /> ***For patients with mod-severe renal impairment<br /> <br /> ==Special Populations==<br /> *[[Drug pregnancy categories|Pregnancy Rating]]: C; Benefits outweigh risks during pregnancy<br /> *Lactation risk: L3; Safety unknown<br /> <br /> ===Renal Dosing===<br /> *Adult: No adjustment<br /> *Pediatric: Not defined<br /> ===Hepatic Dosing===<br /> *Adult: No adjustment<br /> *Pediatric: Not defined<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *[[Anaphylaxis]]<br /> <br /> ===Common===<br /> *Paresthesia<br /> *Flushing<br /> *[[Nausea]]/[[Vomiting]]<br /> <br /> ==Pharmacology==<br /> *Half-life: 5.6 hr, 8.2 hr (Crcl &lt; 30)<br /> *Metabolism: Unknown<br /> *Excretion: Unknown<br /> <br /> ==Mechanism of Action==<br /> *Hydrolyzes carboxyl-terminal glutamate, converting methotrexate to inactive metabolisms.<br /> <br /> ==Comments==<br /> <br /> <br /> ==See Also==<br /> [[Methotrexate toxicity]]<br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Pharmacology]]</div>

Jonwarren