Ostermayer: Created page with "==General== Type: Is Generation::Oxacephem Is DrugClass::Cephalosporin Dosage Forms: powder for injection Dosage Strengths: 1g Routes of Administration: IV, IM Common Trade Names: Flomox ==Adult Dosing== ===General=== Standard: 1-2g IM/IV daily divided q8-12h Severe: Up to 4g/day IM/IV divided q6-8h Max: 4g/day ===UTI, Complicated=== 1g IM/IV q12h ===Intra-abdominal Infections=== 1-2g IM/IV q8-12h *Provides excellent coverage against anaerobes (e..."

2026-01-28T20:09:14Z

Created page with "==General== *Type: Is Generation::Oxacephem Is DrugClass::Cephalosporin *Dosage Forms: powder for injection *Dosage Strengths: 1g *Routes of Administration: IV, IM *Common Trade Names: Flomox ==Adult Dosing== ===General=== *Standard: 1-2g IM/IV daily divided q8-12h *Severe: Up to 4g/day IM/IV divided q6-8h *Max: 4g/day ===UTI, Complicated=== *1g IM/IV q12h ===Intra-abdominal Infections=== *1-2g IM/IV q8-12h *Provides excellent coverage against anaerobes (e..."

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==General==
*Type: [[Is Generation::Oxacephem]] [[Is DrugClass::Cephalosporin]]
*Dosage Forms: powder for injection
*Dosage Strengths: 1g
*Routes of Administration: IV, IM
*Common Trade Names: Flomox

==Adult Dosing==
===General===
*Standard: 1-2g IM/IV daily divided q8-12h
*Severe: Up to 4g/day IM/IV divided q6-8h
*Max: 4g/day

===[[UTI]], Complicated===
*1g IM/IV q12h

===Intra-abdominal Infections===
*1-2g IM/IV q8-12h
*Provides excellent coverage against anaerobes (e.g., Bacteroides fragilis)

===Respiratory Tract Infections===
*1-2g IM/IV divided q8-12h

==Pediatric Dosing==
===General===
*Standard: 60-80 mg/kg/day IM/IV divided q6-8h
*Severe: Up to 150 mg/kg/day IM/IV divided q6-8h

==Special Populations==
*Pregnancy: B
*Lactation: Excreted in breast milk; use with caution
*Renal
**Adult
***CrCl 50-70: No adjustment usually required
***CrCl 20-49: 1g q12h
***CrCl 10-19: 1g q24h
***CrCl <10: 500mg-1g q24h
***Hemodialysis: Administer dose after dialysis
**Pediatric
***Renal impairment requires interval extension based on GFR
*Hepatic
**No adjustment defined

==Contraindications==
*Allergy to class/drug (Oxacephems or Cephalosporins)
*History of anaphylactic shock

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*[[Stevens-Johnson Syndrome]]
*[[Clostridium difficile]]
*Bleeding Diathesis (Risk is significantly lower than with Latamoxef/Moxalactam, but class vigilance is often maintained)
*[[Seizures]] (in high doses/renal failure)

===Common===
*[[Diarrhea]]
*[[Rash]]
*[[Nausea and Vomiting]]
*[[Abdominal Pain]]
*Transaminitis
*Eosinophilia

==Pharmacology==
*Half-life: ~50 minutes
*Metabolism: Minimally metabolized
*Excretion: Urine (largely unchanged)
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis.
*Structure Note: An oxacephem antibiotic where the sulfur atom in the dihydrothiazine ring of the cephalosporin nucleus is replaced by an oxygen atom, conferring stability against beta-lactamases and activity against anaerobes.

==[[Antibiotic Sensitivities]]<ref>Sanford Guide / Japanese Journal of Antibiotics</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||'''S'''
|-
| ||[[N. meningitidis]]||'''S'''
|-
| ||[[Moraxella catarrhalis]]||'''S'''
|-
| ||[[H. influenzae]]||'''S'''
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||I
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||I
|-
| ||Serratia marcescens||I
|-
| ||[[Salmonella]] sp||'''S'''
|-
| ||[[Shigella]] sp||'''S'''
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||'''S'''
|-
| ||[[Providencia sp.]]||'''S'''
|-
| ||[[Morganella sp.]]||'''S'''
|-
| ||[[Citrobacter freundii]]||I
|-
| ||[[Citrobacter diversus]]||'''S'''
|-
| ||[[Citrobacter sp.]]||I
|-
| ||[[Aeromonas sp]]||'''S'''
|-
| ||[[Acinetobacter sp.]]||R
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||'''S'''
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||X1
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||R
|-
| ||[[Mycoplasm pneumoniae]]||R
|-
| ||[[Rickettsia sp]]||R
|-
| ||[[Mycobacterium avium]]||R
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||'''S'''
|-
| ||[[Prevotella melaninogenica]]||'''S'''
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||'''S'''
|-
| ||[[Fusobacterium necrophorum]]||'''S'''
|-
| ||[[Peptostreptococcus sp.]]||'''S'''
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]

Flomoxef - Revision history