Erythema toxicum neonatorum - Revision history

Danbot: Expand with concise EM-focused content: palms/soles sparing, HSV differential, Wright stain with eosinophils

2026-03-21T01:26:58Z

Expand with concise EM-focused content: palms/soles sparing, HSV differential, Wright stain with eosinophils

← Older revision		Revision as of 01:26, 21 March 2026
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	==Background==		==Background==
	{{Skin anatomy background images}}		{{Skin anatomy background images}}
	*~~Benign~~, ~~self-limited (1wk) rash that occurs~~ in 50% of ~~newborns~~		*Most common benign rash of newborns, occurring in ~50% of full-term neonates
	*~~Thought~~ to be ~~problem with sebaceous glands within~~ hair follicles		*Self-limited condition lasting ~1-2 weeks
			*Etiology unclear; thought to be related to activation of the innate immune system at hair follicles
			*Onset typically 24-72 hours after birth, but can appear up to 2 weeks of age
			*Incidence declines with decreasing gestational age (rare in preterm infants)

	==Clinical Features==		==Clinical Features==
	[[File:Erythema toxcium.png\|thumb\|Erythema toxicum]]		[[File:Erythema toxcium.png\|thumb\|Erythema toxicum]]
	*Erythematous [[rash\|macules]] ~~develop~~ on face, trunk, extremities		*Erythematous [[rash\|macules]], papules, and pustules on a blotchy erythematous base
	*Spares palms and soles		*Distribution: face, trunk, proximal extremities
	*~~Most common with full term infants~~, ~~with incidence declining with decreasing gestational age~~		*'''Spares palms and soles''' (key distinguishing feature)
			*Lesions are evanescent — appear, fade, and reappear in different locations over hours to days
			*Infant is well-appearing, afebrile, feeding normally

	==Differential Diagnosis==		==Differential Diagnosis==
	{{Neonatal rashes DDX}}		{{Neonatal rashes DDX}}
			*'''Key differentials to consider:'''
			**Neonatal [[herpes simplex virus\|HSV]]: clustered vesicles, ill-appearing infant, fever
			**[[Staphylococcal scalded skin syndrome]]: widespread erythema, skin tenderness, desquamation
			**Transient neonatal pustular melanosis: pustules on non-erythematous base, present at birth

	==Evaluation==		==Evaluation==
	*~~Normally clinical~~		*Clinical diagnosis in a well-appearing neonate
			*If diagnosis uncertain: Wright stain of pustule contents shows '''eosinophils''' (pathognomonic)
			*No labs, cultures, or imaging needed if classic presentation

	==Management==		==Management==
	*No treatment necessary		*No treatment necessary — reassurance to parents
			*Resolves spontaneously within 1-2 weeks without sequelae

	==Disposition==		==Disposition==
	*~~Outpatient~~		*Discharge with parental reassurance
			*No follow-up needed unless atypical features

	==See Also==		==See Also==
	*[[Neonatal ~~Rashes~~]]		*[[Neonatal rashes]]
			*[[Transient neonatal pustular melanosis]]

			==References==
			<references/>

	[[Category:Dermatology]]		[[Category:Dermatology]]
	[[Category:Pediatrics]]		[[Category:Pediatrics]]

Rossdonaldson1: /* Background */

2024-12-11T16:23:49Z

Background

← Older revision		Revision as of 16:23, 11 December 2024
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	==Background==		==Background==
			{{Skin anatomy background images}}
	*Benign, self-limited (1wk) rash that occurs in 50% of newborns		*Benign, self-limited (1wk) rash that occurs in 50% of newborns
	*Thought to be problem with sebaceous glands within hair follicles		*Thought to be problem with sebaceous glands within hair follicles

ClaireLewis at 21:42, 5 October 2019

2019-10-05T21:42:26Z

← Older revision		Revision as of 21:42, 5 October 2019
Line 5:		Line 5:
	==Clinical Features==		==Clinical Features==
	[[File:Erythema toxcium.png\|thumb\|Erythema toxicum]]		[[File:Erythema toxcium.png\|thumb\|Erythema toxicum]]
	*Erythematous [[rash\|macules]]] develop on face, trunk, extremities		*Erythematous [[rash\|macules]] develop on face, trunk, extremities
	*Spares palms and soles		*Spares palms and soles
	*Most common with full term infants, with incidence declining with decreasing gestational age		*Most common with full term infants, with incidence declining with decreasing gestational age

ClaireLewis: /* Clinical Features */

2019-09-27T22:29:08Z

Clinical Features

← Older revision		Revision as of 22:29, 27 September 2019
Line 5:		Line 5:
	==Clinical Features==		==Clinical Features==
	[[File:Erythema toxcium.png\|thumb\|Erythema toxicum]]		[[File:Erythema toxcium.png\|thumb\|Erythema toxicum]]
	*Erythematous macules develop on face, trunk, extremities		*Erythematous [[rash\|macules]]] develop on face, trunk, extremities
	*Spares palms and soles		*Spares palms and soles
	*Most common with full term infants, with incidence declining with decreasing gestational age		*Most common with full term infants, with incidence declining with decreasing gestational age

Kxl328: /* Clinical Features */

2018-09-30T20:03:06Z

Clinical Features

← Older revision		Revision as of 20:03, 30 September 2018
Line 6:		Line 6:
	[[File:Erythema toxcium.png\|thumb\|Erythema toxicum]]		[[File:Erythema toxcium.png\|thumb\|Erythema toxicum]]
	*Erythematous macules develop on face, trunk, extremities		*Erythematous macules develop on face, trunk, extremities
			*Spares palms and soles
			*Most common with full term infants, with incidence declining with decreasing gestational age

	==Differential Diagnosis==		==Differential Diagnosis==

Kxl328: /* Background */

2018-09-30T20:02:07Z

Background

← Older revision		Revision as of 20:02, 30 September 2018
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	==Background==		==Background==
	*Benign, self-limited (1wk) rash that occurs in 50% of newborns		*Benign, self-limited (1wk) rash that occurs in 50% of newborns
			*Thought to be problem with sebaceous glands within hair follicles

	==Clinical Features==		==Clinical Features==

Rossdonaldson1: /* Evaluation */

2017-04-27T11:29:32Z

Evaluation

← Older revision		Revision as of 11:29, 27 April 2017
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	==Evaluation==		==Evaluation==
			*Normally clinical

	==Management==		==Management==

Rossdonaldson1 at 11:27, 27 April 2017

2017-04-27T11:27:02Z

← Older revision		Revision as of 11:27, 27 April 2017
Line 3:		Line 3:

	==Clinical Features==		==Clinical Features==
			[[File:Erythema toxcium.png\|thumb\|Erythema toxicum]]
	*Erythematous macules develop on face, trunk, extremities		*Erythematous macules develop on face, trunk, extremities

Rossdonaldson1: Rossdonaldson1 moved page Erythema toxicum to Erythema toxicum neonatorum

2017-04-27T11:23:58Z

Rossdonaldson1 moved page Erythema toxicum to Erythema toxicum neonatorum

← Older revision	Revision as of 11:23, 27 April 2017
(No difference)

Rossdonaldson1 at 11:23, 27 April 2017

2017-04-27T11:23:21Z

← Older revision		Revision as of 11:23, 27 April 2017
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	*Benign, self-limited (1wk) rash that occurs in 50% of newborns		*Benign, self-limited (1wk) rash that occurs in 50% of newborns

	==~~Evaluation~~==		==Clinical Features==
	*Erythematous macules develop on face, trunk, extremities		*Erythematous macules develop on face, trunk, extremities

	==Differential Diagnosis==		==Differential Diagnosis==
	{{Neonatal rashes DDX}}		{{Neonatal rashes DDX}}

			==Evaluation==

	==Management==		==Management==
	*No treatment necessary		*No treatment necessary

			==Disposition==
			*Outpatient

	==See Also==		==See Also==