Dexmedetomidine - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:57:19Z

Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T17:26:09Z

Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

2026-03-20T16:44:10Z

Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

@@ Line 56: / Line 56: @@
 *Provides sedation with maintenance of arousability, airway protection
 *Preserves sleep architecture and decreases incidence of ICU delirium <ref>Skrobik, Y., Duprey, M., Hill, N. and Devlin, J., 2018. Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial. American Journal of Respiratory and Critical Care Medicine, 197(9), pp.1147-1156.</ref>
 ==See Also==

2020-11-29T17:01:26Z

Comments

← Older revision		Revision as of 17:01, 29 November 2020
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	*Hemodynamically neutral medication		*Hemodynamically neutral medication
	*Provides sedation with maintenance of arousability, airway protection		*Provides sedation with maintenance of arousability, airway protection
			*Preserves sleep architecture and decreases incidence of ICU delirium <ref>Skrobik, Y., Duprey, M., Hill, N. and Devlin, J., 2018. Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial. American Journal of Respiratory and Critical Care Medicine, 197(9), pp.1147-1156.</ref>

	==See Also==		==See Also==

2019-09-20T23:53:56Z

References

2019-09-20T23:53:41Z

← Older revision		Revision as of 23:53, 20 September 2019
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	==General==		==General==
	*Type: [[Alpha-2 ~~agonist~~]]; [[Sedative agents]]		*Type: [[Alpha-2 agonists]]; [[Sedative agents]]
	*Dosage Forms:IV		*Dosage Forms:IV
	*Common Trade Names: Precedex (US), Dexdor (European)		*Common Trade Names: Precedex (US), Dexdor (European)
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	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:Critical care]]

2019-01-16T16:36:04Z

Adult Dosing

← Older revision		Revision as of 16:36, 16 January 2019
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	==Adult Dosing==		==Adult Dosing==
	*[[ICU Sedation]]: 1 mcg/kg over 10 minutes ~~followed~~ by 0.2 to 0.7 mcg/kg/hr		===[[ICU Sedation]]===
	*[[Procedural Sedation]]: 1 mcg/kg over 10 minutes ~~followed~~ by 0.6 mcg/hr titrated to effect, generally 0.2 to 1 mcg/kg/hr		*1 mcg/kg over 10 minutes
			**Followed by 0.2 to 0.7 mcg/kg/hr

			===[[Procedural Sedation]]===
			*1 mcg/kg over 10 minutes
			**Followed by 0.6 mcg/hr titrated to effect (generally 0.2 to 1 mcg/kg/hr)

	==Pediatric Dosing==		==Pediatric Dosing==

2019-01-16T16:35:21Z

Post-Intubation Sedation

← Older revision		Revision as of 16:35, 16 January 2019
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	==Pediatric Dosing==		==Pediatric Dosing==
	===Post-Intubation Sedation===		===[[ICU sedation\|Post-Intubation Sedation]]===
	*Do not bolus		*Do not bolus
	*Start at 0.2-0.4 mcg/kg/hour and titrate to a max of 1.4 mcg/kg/hour		*Start at 0.2-0.4 mcg/kg/hour and titrate to a max of 1.4 mcg/kg/hour

2019-01-16T16:34:55Z

Pediatric Dosing

← Older revision		Revision as of 16:34, 16 January 2019
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	==Pediatric Dosing==		==Pediatric Dosing==
			===Post-Intubation Sedation===
			*Do not bolus
			*Start at 0.2-0.4 mcg/kg/hour and titrate to a max of 1.4 mcg/kg/hour
			**Recommended to start at 0.4 mcg/kg/hour for agitated patients
			*Make changes every 15-20 minutes if not desired affect or sooner if patient is agitated
			*May use with spot does of other medications like fentanyl and versed.
			**If on fentanyl or versed drip already should be able to titrate the dose down.

	==Special Populations==		==Special Populations==

2017-07-24T01:13:17Z

Text replacement - "alpha" to "α"

← Older revision		Revision as of 01:13, 24 July 2017
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	*Metabolism: Hepatic		*Metabolism: Hepatic
	*Excretion: Renal		*Excretion: Renal
	*Mechanism of Action: Selective ~~alpha~~-2 agonist		*Mechanism of Action: Selective α-2 agonist

	==Comments==		==Comments==