Colistimethate - Revision history

ClaireLewis at 17:56, 20 September 2019

2019-09-20T17:56:11Z

← Older revision		Revision as of 17:56, 20 September 2019
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	==General==		==General==
	*Type:		*Type: [[Antibiotic]]
	*Dosage Forms:		*Dosage Forms: IV
	*Common Trade Names:		*Common Trade Names:

	==Adult Dosing==		==Adult Dosing==
			*2.5-5 mg/kg/day divided q6-12hr IV/IM; not to exceed 5 mg/kg/day

	==Pediatric Dosing==		==Pediatric Dosing==
			*<12yo: safety/efficacy not established

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]:		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C
	*Lactation:		*Lactation: Unknown, use caution
	*Renal Dosing		*Renal Dosing
	**~~Adult~~		**CrCl 50-79 mL/min: 2.5-3.8 mg/kg/day IV/IM divided q12hr
	**~~Pediatric~~		**CrCl 30-49 mL/min: 2.5 mg/kg/day IV/IM qDay or divided q12hr
	*~~Hepatic Dosing~~		**CrCl 10-29 mL/min: 1.5 mg/kg IV/IM q36hr
	**Adult		*Hepatic Dosing: Not established
	**Pediatric

	==Contraindications==		==Contraindications==
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	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
			*Anaphylaxis
			*Acute respiratory failure, particularly in myasthenia gravis or recent use of NMJ blockade
			*Nephrotoxicity
			*Neurotoxicity, seizures
			*C. diff pseudomembranous colitis
	===Common===		===Common===
			*Dizziness
			*Paresthesias
			*Dysarthria

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 2-3h
	*Metabolism:		*Metabolism:
	*Excretion:		*Excretion: Urine
	*Mechanism of Action:		*Mechanism of Action: "Cationic detergent that damages bacterial cytoplasmic membrane, causing cell death"<ref>https://reference.medscape.com/drug/colistimethate-sodium-coly-mycin-m-colistin-342578#10</ref>

	==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==		==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==
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	==References==		==References==
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]] [[Category:ID]]

Mholtz: Text replacement - "==References== " to "==References== "

2017-10-25T04:36:04Z

Text replacement - "==References== <references/>" to "==References== <references/>"

← Older revision		Revision as of 04:36, 25 October 2017
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	==References==		==References==

	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Mholtz: Text replacement - "==Source==" to "==References=="

2017-09-05T02:21:00Z

Text replacement - "==Source==" to "==References=="

← Older revision		Revision as of 02:21, 5 September 2017
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	==See Also==		==See Also==

	==~~Source~~==		==References==

	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Ostermayer: Text replacement - "Category:Drugs" to "Category:Pharmacology"

2016-03-22T15:53:49Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"

← Older revision		Revision as of 15:53, 22 March 2016
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	<references/>		<references/>
	[[Category:~~Drugs~~]]		[[Category:Pharmacology]]

Rossdonaldson1 at 00:51, 19 September 2014

2014-09-19T00:51:12Z

← Older revision		Revision as of 00:51, 19 September 2014
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	<references/>		<references/>
			[[Category:Drugs]]

Rossdonaldson1: Created page with "==General== Type: Dosage Forms: Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== Pregnancy Rating: *Lac..."

2014-06-26T05:06:11Z

Created page with "==General== *Type: *Dosage Forms: *Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== *Pregnancy Rating: *Lac..."

New page

==General==
*Type:
*Dosage Forms:
*Common Trade Names:

==Adult Dosing==

==Pediatric Dosing==

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
*Lactation:
*Renal Dosing
**Adult
**Pediatric
*Hepatic Dosing
**Adult
**Pediatric

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===

===Common===

==Pharmacology==
*Half-life:
*Metabolism:
*Excretion:
*Mechanism of Action:

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||R
|-
| ||[[Strep. Pneumoniae]]||R
|-
| ||[[Viridans strep]]||X1
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||R
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||R
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||R
|-
| ||[[N. meningitidis]]||R
|-
| ||[[Moraxella catarrhalis]]||X1
|-
| ||[[H. influenzae]]||X1
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||'''S'''
|-
| ||E coli/Klebsiella KPC+||'''S'''
|-
| ||[[Enterobacter]] sp, AmpC neg||'''S'''
|-
| ||[[Enterobacter]] sp, AmpC pos||'''S'''
|-
| ||[[Serratia]] sp||X1
|-
| ||Serratia marcescens||R
|-
| ||[[Salmonella]] sp||X1
|-
| ||[[Shigella]] sp||X1
|-
| ||[[Proteus mirabilis]]||X1
|-
| ||[[Proteus vulgaris]]||R
|-
| ||[[Providencia sp.]]||X1
|-
| ||[[Morganella sp.]]||X1
|-
| ||[[Citrobacter freundii]]||X1
|-
| ||[[Citrobacter diversus]]||X1
|-
| ||[[Citrobacter sp.]]||X1
|-
| ||[[Aeromonas sp]]||X1
|-
| ||[[Acinetobacter sp.]]||'''S'''
|-
| ||[[Pseudomonas aeruginosa]]||'''S'''
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||I
|-
| ||[[Yersinia enterocolitica]]||X1
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||X1
|-
| ||[[Pasteurella multocida]]||X1
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||X1
|-
| ||[[Mycoplasm pneumoniae]]||X1
|-
| ||[[Rickettsia sp]]||X1
|-
| ||[[Mycobacterium avium]]||X1
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||X1
|-
| ||[[Prevotella melaninogenica]]||X1
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||X1
|-
| ||[[Fusobacterium necrophorum]]||X1
|-
| ||[[Peptostreptococcus sp.]]||X1
|}

===Key===
{{Template:Antibacterial Spectra Key}}
==See Also==

==Source==

<references/>