Chronic myeloid leukemia - Revision history

ClaireLewis at 00:11, 1 October 2019

2019-10-01T00:11:15Z

← Older revision		Revision as of 00:11, 1 October 2019
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	===Chronic phase===		===Chronic phase===
	*Asymptomatic or indolent, nonspecific symptoms		*Asymptomatic or indolent, nonspecific symptoms
	*Malaise, fatigue, weight loss, low grade fever		*Malaise, [[fatigue]], weight loss, low grade [[fever]]
	*Lymphadenopathy, splenomegaly		*[[Lymphadenopathy]], splenomegaly

	===Accelerated phase===		===Accelerated phase===
	*Worsening of above symptoms due to progressive leukocytosis		*Worsening of above symptoms due to progressive [[leukocytosis]]
	*Signs/symptoms of [[thrombocytopenia]] (e.g. petechiae, bleeding) or thrombocytosis		*Signs/symptoms of [[thrombocytopenia]] (e.g. [[petechiae]], [[hemorrhage\|bleeding]]) or [[thrombocytosis]]

	===Blast crisis===		===Blast crisis===
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	==Disposition==		==Disposition==
			*Can consider discharging asymptomatic patients in chronic phase who have no complications and close follow-up. Otherwise, admit.

	==See Also==		==See Also==

2016-12-22T21:40:48Z

Management

← Older revision		Revision as of 21:40, 22 December 2016
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	==Management==		==Management==
	*See management of [[Leukostasis and hyperleukocytosis]], [[neutropenic fever]], [[hyperviscosity syndrome]], [[tumor lysis syndrome]], [[thrombocytopenia]]		*See management of [[Leukostasis and hyperleukocytosis]], [[neutropenic fever]], [[hyperviscosity syndrome]], [[DIC]], [[tumor lysis syndrome]], [[thrombocytopenia]], [[anemia]]

	==Disposition==		==Disposition==

2016-09-24T06:17:37Z

Background

← Older revision		Revision as of 06:17, 24 September 2016
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	==Background==		==Background==
	*~~aka~~ chronic myelogenous leukemia, chronic myelocytic leukemia		*Also known as chronic myelogenous leukemia, chronic myelocytic leukemia
	*More common in older patients		*More common in older patients

2016-09-24T06:17:11Z

Differential Diagnosis

2016-09-24T06:13:18Z

Evaluation

← Older revision		Revision as of 06:13, 24 September 2016
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	==Evaluation==		==Evaluation==
	*CBC		*CBC
	**Leukocytosis: usually only moderately elevated in chronic phase (20,000-60,000)		**[[Leukocytosis]]: usually only moderately elevated in chronic phase (20,000-60,000)
	**Mild-moderate [[anemia]]		**Mild-moderate [[anemia]]
	**Variable platelet counts		**Variable platelet counts

2016-09-24T06:13:09Z

Evaluation

← Older revision		Revision as of 06:13, 24 September 2016
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	==Evaluation==		==Evaluation==
	*CBC-		*CBC
	**Leukocytosis: usually only moderately elevated in chronic phase (20,000-60,000)		**Leukocytosis: usually only moderately elevated in chronic phase (20,000-60,000)
	**Mild-moderate [[anemia]]		**Mild-moderate [[anemia]]

2016-09-24T06:12:57Z

=Blast crisis]

← Older revision		Revision as of 06:12, 24 September 2016
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	*Signs/symptoms of [[thrombocytopenia]] (e.g. petechiae, bleeding) or thrombocytosis		*Signs/symptoms of [[thrombocytopenia]] (e.g. petechiae, bleeding) or thrombocytosis

	===Blast crisis]==		===Blast crisis===
	*Behaves like [[acute leukemia]]		*Behaves like [[acute leukemia]]
	*Associated with [[Leukostasis and hyperleukocytosis]] and [[Hyperviscosity syndrome]]		*Associated with [[Leukostasis and hyperleukocytosis]] and [[Hyperviscosity syndrome]]

2016-09-24T06:08:08Z

Blast crisis

← Older revision		Revision as of 06:08, 24 September 2016
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	*Signs/symptoms of [[thrombocytopenia]] (e.g. petechiae, bleeding) or thrombocytosis		*Signs/symptoms of [[thrombocytopenia]] (e.g. petechiae, bleeding) or thrombocytosis

	===Blast crisis===		===Blast crisis]==
	*Behaves like [[acute leukemia]]		*Behaves like [[acute leukemia]]
	*Associated with [[Leukostasis and hyperleukocytosis]] and [[Hyperviscosity syndrome]]		*Associated with [[Leukostasis and hyperleukocytosis]] and [[Hyperviscosity syndrome]]

2016-09-24T06:07:51Z

Clinical Features

← Older revision		Revision as of 06:07, 24 September 2016
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	==Clinical Features==		==Clinical Features==
	*Usually progresses through 3 stages:		''Usually progresses through 3 stages''
	*Chronic phase
	**Asymptomatic or indolent, nonspecific symptoms		===Chronic phase===
	**Malaise, fatigue, weight loss, low grade fever		*Asymptomatic or indolent, nonspecific symptoms
	**Lymphadenopathy, splenomegaly		*Malaise, fatigue, weight loss, low grade fever
	*Accelerated phase		*Lymphadenopathy, splenomegaly
	**Worsening of above symptoms due to progressive leukocytosis
	**Signs/symptoms of [[thrombocytopenia]] (e.g. petechiae, bleeding) or thrombocytosis		===Accelerated phase===
	*Blast crisis		*Worsening of above symptoms due to progressive leukocytosis
	**Behaves like [[acute leukemia]]		*Signs/symptoms of [[thrombocytopenia]] (e.g. petechiae, bleeding) or thrombocytosis
	**Associated with [[Leukostasis and hyperleukocytosis]] and [[Hyperviscosity syndrome]]
			===Blast crisis===
			*Behaves like [[acute leukemia]]
			*Associated with [[Leukostasis and hyperleukocytosis]] and [[Hyperviscosity syndrome]]

	==Differential Diagnosis==		==Differential Diagnosis==

2016-09-24T05:56:48Z

Differential Diagnosis