Celecoxib - Revision history

Danbot: Add peer-reviewed reference

2026-03-22T10:17:41Z

Add peer-reviewed reference

← Older revision		Revision as of 10:17, 22 March 2026
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	==Administration==		==Administration==
	*Type: [[Nonsteroidal anti-inflammatory drugs]] (NSAID), COX-2 Selective		*Type: [[Nonsteroidal anti-inflammatory drugs]] (NSAID), COX-2 Selective<ref>Nissen SE, et al. Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis. N Engl J Med. 2016;375(26):2519-2529. PMID 27959716</ref>
	*Dosage Forms: capsule		*Dosage Forms: capsule
	*Dosage Strengths: 50, 100, 200, 400mg		*Dosage Strengths: 50, 100, 200, 400mg

2021-03-07T22:54:15Z

2017-10-13T18:33:47Z

Mechanism of Action: added mechanism

← Older revision		Revision as of 18:33, 13 October 2017
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	==Mechanism of Action==		==Mechanism of Action==
			Inhibits cyclooxygenase (COX)-2; does not affect COX-1 (at therapeutic concentrations), thereby decreasing formation of prostaglandin synthesis

	==Comments==		==Comments==

2017-10-13T18:31:55Z

edited dosage forms, strengths, routes of administration, trade names

← Older revision		Revision as of 18:31, 13 October 2017
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	==Administration==		==Administration==
	*Type: [[Nonsteroidal anti-inflammatory drugs]] (NSAID), COX-2 Selective		*Type: [[Nonsteroidal anti-inflammatory drugs]] (NSAID), COX-2 Selective
	*Dosage Forms: 50,100,200,~~400~~		*Dosage Forms: capsule
	*Routes of Administration: ~~Oral~~		*Dosage Strengths: 50, 100, 200, 400mg
	*Common Trade Names: ~~CeleBREX~~		*Routes of Administration: PO
			*Common Trade Names: Celebrex

	==Adult Dosing==		==Adult Dosing==

2017-07-07T12:54:42Z

Text replacement - "qd" to "QD"

← Older revision		Revision as of 12:54, 7 July 2017
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	==Adult Dosing==		==Adult Dosing==
	*[[Osteoarthritis]]: 200mg PO qd		*[[Osteoarthritis]]: 200mg PO QD

	*[[Rheumatoid arthritis]]: 100-200mg PO bid		*[[Rheumatoid arthritis]]: 100-200mg PO bid
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	**Consider starting at 50% of lowest dose if poor CYP2C9 metabolizer		**Consider starting at 50% of lowest dose if poor CYP2C9 metabolizer

	*[[Ankylosing spondylitis]]: 200mg PO qd		*[[Ankylosing spondylitis]]: 200mg PO QD
	**Max: 400mg/day		**Max: 400mg/day

2016-07-19T01:25:40Z

Text replacement - "0 mg" to "0mg"

← Older revision		Revision as of 01:25, 19 July 2016
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	==Adult Dosing==		==Adult Dosing==
	*[[Osteoarthritis]]: ~~200 mg~~ PO qd		*[[Osteoarthritis]]: 200mg PO qd

	*[[Rheumatoid arthritis]]: 100-~~200 mg~~ PO bid		*[[Rheumatoid arthritis]]: 100-200mg PO bid
	**Use lowest effective dose, shortest effective treatment duration		**Use lowest effective dose, shortest effective treatment duration
	**Consider starting at 50% of lowest dose if poor CYP2C9 metabolizer		**Consider starting at 50% of lowest dose if poor CYP2C9 metabolizer

	*[[Ankylosing spondylitis]]: ~~200 mg~~ PO qd		*[[Ankylosing spondylitis]]: 200mg PO qd
	**Max: ~~400 mg~~/day		**Max: 400mg/day

	*[[Dysmenorrhea]]: ~~200 mg~~ PO bid		*[[Dysmenorrhea]]: 200mg PO bid
	**Start: ~~400 mg~~ PO x1, may give additional ~~200 mg~~ on day 1 if needed		**Start: 400mg PO x1, may give additional 200mg on day 1 if needed

	*Pain, acute: ~~200 mg~~ PO bid		*Pain, acute: 200mg PO bid
	**Start: ~~400 mg~~ PO x1, may give additional ~~200 mg~~ on day 1 if needed		**Start: 400mg PO x1, may give additional 200mg on day 1 if needed

	==Pediatric Dosing==		==Pediatric Dosing==
	===Only for ages > 2 years old===		===Only for ages > 2 years old===
	*[[Juvenile idiopathic arthritis ]]		*[[Juvenile idiopathic arthritis ]]
	**10-25 kg]: ~~50 mg~~ PO bid		**10-25 kg]: 50mg PO bid
	**>25 kg: ~~100 mg~~ PO bid		**>25 kg: 100mg PO bid

	==Special Populations==		==Special Populations==

2016-07-15T20:50:05Z

Hepatic Dosing

← Older revision		Revision as of 20:50, 15 July 2016
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	===Hepatic Dosing===		===Hepatic Dosing===
	*Adult:Child-Pugh Class B: ~~decr.~~ dose 50%; Child-Pugh Class C: avoid use		*Adult:Child-Pugh Class B: decrease dose 50%; Child-Pugh Class C: avoid use

	==Contraindications==		==Contraindications==

2016-07-14T21:18:33Z

Text replacement - "tx" to "treatment"

← Older revision		Revision as of 21:18, 14 July 2016
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	*[[Rheumatoid arthritis]]: 100-200 mg PO bid		*[[Rheumatoid arthritis]]: 100-200 mg PO bid
	**Use lowest effective dose, shortest effective tx duration		**Use lowest effective dose, shortest effective treatment duration
	**Consider starting at 50% of lowest dose if poor CYP2C9 metabolizer		**Consider starting at 50% of lowest dose if poor CYP2C9 metabolizer

2016-07-12T06:01:02Z

Adverse Reactions

2016-07-12T06:00:37Z

Contraindications

← Older revision		Revision as of 06:00, 12 July 2016
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	*hypersens. to drug/class/compon.		*hypersens. to drug/class/compon.
	*hypersens. to sulfonamides		*hypersens. to sulfonamides
	*ASA or NSAID-induced asthma or urticaria		*[[ASA]] or [[NSAID]]-induced [[asthma]] or [[urticaria]]
	*aspirin triad		*aspirin triad
	*pregnancy starting at 30 wk gestation		*pregnancy starting at 30 wk gestation
	*CABG surgery periop use		*CABG surgery periop use
	*GI bleeding		*[[GI bleeding]]

	==Adverse Reactions==		==Adverse Reactions==