https://wikem.org/w/index.php?action=history&feed=atom&title=Bismuth_subsalicylate%2Fen 2026-04-20T12:28:46Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Bismuth_subsalicylate/en&diff=380267&oldid=prev 2026-01-06T21:30:23Z

<p>Updating to match new version of source page</p> <p><b>New page</b></p><div>&lt;languages/&gt;<br /> <br /> ==Administration==<br /> <br /> *Type: Anti-[[Special:MyLanguage/diarrhea|diarrhea]]l<br /> *Dosage Forms:<br /> *Routes of Administration: PO<br /> *Common Trade Names: Pepto Bismol, Maalox<br /> <br /> <br /> ==Adult Dosing==<br /> <br /> *[[Special:MyLanguage/Diarrhea|Diarrhea]], gas, indigestion, heartburn, [[Special:MyLanguage/nausea|nausea]]: 524mg (2 tabs regular strength) PO q30m PRN, max 8 doses regular strength or 4 doses extra-strength daily<br /> *[[Special:MyLanguage/H. pylori|H. pylori]]: 524mg (2 regular-strength tablets or 1 extra-strength tablet) + 250 mg metronidazole + 500 mg tetracycline PO q6hr x14d, plus H2 antagonist<br /> <br /> <br /> ==Pediatric Dosing==<br /> <br /> *&lt;3y: safety/efficacy not established<br /> *2-6y: 87mg PO q30-60m PRN<br /> *6-9y: 175mg PO q30-60m PRN<br /> *9-12y: 262mg PO q30-60m PRN<br /> *&gt;12y: adult dose<br /> <br /> <br /> ==Special Populations==<br /> <br /> <br /> ===[[Special:MyLanguage/Drug pregnancy categories|Pregnancy Rating]]===<br /> <br /> *Category C, Category D in 3rd trimester<br /> <br /> <br /> ===Lactation risk===<br /> <br /> *Salicylates enter breastmilk; use with caution<br /> <br /> <br /> ===Renal Dosing===<br /> <br /> *Caution: overdose may cause nephrotoxicity<br /> <br /> <br /> ===Hepatic Dosing===<br /> <br /> <br /> ==Contraindications==<br /> <br /> *Allergy to class/drug<br /> *Infectious diarrhea (fever)<br /> *von Willebrand disease, hemorrhage, ulcer, GI bleeding, hemophilia<br /> *In pediatric patients; chicken pox or influenza (risk of [[Special:MyLanguage/Reye syndrome|Reye syndrome]])<br /> <br /> <br /> ==Adverse Reactions==<br /> <br /> <br /> ===Serious===<br /> <br /> *Duodenal ulcer, GI hemorrhage<br /> *Neurotoxicity<br /> *Renal failure<br /> <br /> <br /> ===Common===<br /> <br /> *Nausea, diarrhea, abdominal pain, constipation, anorexia, dyspepsia, flatulence, anal discomfort<br /> *Black stool, melena<br /> *URI, sinusitis<br /> *Asthenia<br /> *Discolored tongue, taste perversion <br /> *Headache, dizziness<br /> *Paresthesia<br /> *Anxiety, depression<br /> *Tinnitus<br /> *Muscle spasm<br /> <br /> <br /> ==Pharmacology==<br /> <br /> *Half-life: Bismuth- 21-72 days, salicylate- 2.5h<br /> *Metabolism: GI tract, liver<br /> *Excretion: Bismuth- feces, salicylate- urine<br /> <br /> <br /> ==Mechanism of Action==<br /> <br /> *Bismuth: antimicrobial, anti-inflammatory action<br /> *Salicylate: antisecretory effect<br /> <br /> <br /> ==Comments==<br /> <br /> <br /> ==See Also==<br /> <br /> *[[Special:MyLanguage/Bismuth toxicity|Bismuth toxicity]]<br /> <br /> <br /> ==References==<br /> <br /> https://reference.medscape.com/drug/kaopectate-pepto-bismol-bismuth-subsalicylate-342037#10<br /> &lt;references/&gt;<br /> <br /> [[Category:Pharmacology]]<br /> [[Category:GI]]</div>

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