https://wikem.org/w/index.php?action=history&feed=atom&title=Benznidazole 2026-04-20T20:54:54Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Benznidazole&diff=229034&oldid=prev 2019-09-19T21:30:59Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 21:30, 19 September 2019</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l61">Line 61:</td> <td colspan="2" class="diff-lineno">Line 61:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;references/&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;references/&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pharmacology]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pharmacology<ins style="font-weight: bold; text-decoration: none;">]] [[Category:ID</ins>]]</div></td></tr> </table>

ClaireLewis https://wikem.org/w/index.php?title=Benznidazole&diff=227789&oldid=prev 2019-09-10T16:47:40Z

<p>Created page with &quot;==Administration== *Type: <a href="/wiki/Antiparasitic" title="Antiparasitic">Antiparasitic</a> *Dosage Forms: *Routes of Administration: PO *Common Trade Names: ==Adult Dosing== *Chronic <a href="/wiki/Chagas" class="mw-redirect" title="Chagas">chagas</a> in patients up to age 50 w...&quot;</p> <p><b>New page</b></p><div>==Administration==<br /> *Type: [[Antiparasitic]]<br /> *Dosage Forms:<br /> *Routes of Administration: PO<br /> *Common Trade Names: <br /> <br /> ==Adult Dosing==<br /> *Chronic [[chagas]] in patients up to age 50 without cardiomyopathy: 5-7 mg/kg/day PO divided in 2 doses separated by ~12 hr x 60 days<br /> <br /> ==Pediatric Dosing==<br /> *&lt;2 years: Safety/efficacy not established<br /> *2-12 years: 5-7.5 mg/kg/day PO divided in 2 doses separated by ~12 hr x 60 days<br /> *&gt;12y: 5-7 mg/kg/day PO divided in 2 doses separated by ~12 hr x 60 days<br /> <br /> ==Special Populations==<br /> ===[[Drug pregnancy categories|Pregnancy Rating]]===<br /> *Fetal harm demonstrated in animal studies&lt;ref&gt;https://reference.medscape.com/drug/benznidazole-1000203#6&lt;/ref&gt;<br /> <br /> ===Lactation risk===<br /> *Breastfeeding while being treated with benznidazole not recommended&lt;ref&gt;https://reference.medscape.com/drug/benznidazole-1000203#6&lt;/ref&gt;<br /> <br /> ===Renal Dosing===<br /> *Not established<br /> <br /> ===Hepatic Dosing===<br /> *Not established<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug<br /> *Disulfiram administered within last 2 weeks; psychotic reactions may occur<br /> *Concomitant consumption of ETOH or propylene glycol containing products; disulfiram-like reaction may occur<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *Acute generalized exanthematous pustulosis<br /> *TEN, erythema multiforme, DRESS<br /> *Paresthesias/peripheral neuropathy that can last for several months<br /> *Bone marrow depression (e.g. cytopenias)<br /> <br /> ===Common===<br /> *Headache, dizziness<br /> *Paresthesias, peripheral neuropathy, tremor<br /> *Skin reactions; rash<br /> *Abdominal pain, nausea/vomiting, diarrhea, weight loss, abnormal LFTs<br /> <br /> ==Pharmacology==<br /> *Half-life: 13h<br /> *Metabolism: unknown<br /> *Excretion: urine and feces<br /> <br /> ==Mechanism of Action==<br /> *Inhibits DNA, RNA, and protein synthesis within the T cruzi parasite<br /> <br /> ==Comments==<br /> <br /> <br /> ==See Also==<br /> *[[Chagas disease]]<br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Pharmacology]]</div>

ClaireLewis