Atovaquone - Revision history

Danbot: Restore original dosing content alongside dynamic SMW tables

2026-03-20T02:39:02Z

Restore original dosing content alongside dynamic SMW tables

← Older revision		Revision as of 02:39, 20 March 2026
Line 7:		Line 7:

	==Adult Dosing==		==Adult Dosing==
			*Babesiosis: 750mg PO q12h + azithromycin
			*Toxoplasma encephalitis, HIV+: 1500mg daily + leucovorin +/- pyrimethamine
			*PCP pneumonia (2nd line): 1500mg daily
			*Malaria prophylaxis:

	===Indications by Disease===		===Indications by Disease===
	{{#ask: [[Has DrugName::Atovaquone]] [[Has Population::Adult]]		{{#ask: [[Has DrugName::Atovaquone]] [[Has Population::Adult]]
	\|?Treats disease=Disease		\|?Treats disease=Disease
	\|?Has Dose=Dose		\|?Has Dose=Dose
	\|?Has Context=Context		\|?Has Context=Context
	\|format=table		\|format=table
	\|limit=50		\|limit=50
	\|mainlabel=-		\|mainlabel=-
	\|headers=show		\|headers=show
	\|sort=Treats disease		\|sort=Treats disease
	}}		}}

	==Pediatric Dosing==		==Pediatric Dosing==
			*Babesiosis: 20mg/kg q12h (max 750mg/dose) + azithromycin
			*PCP pneumonia (2nd line)
			**>13yo, HIV- : 1500mg daily
			**Adolescents, HIV+: 1500mg daily +/- leucovorin, +/- pyrimethamine
			**1-3mo, 2-13yo, HIV+: 30 mg/kg PO daily
			**4-24mo, HIV+: 45mg/kg PO daily
			*Malaria prophylaxis: 250mg + 100mg proguanil daily
			*Malaria falciparum/vivax treatment: 1000mg + proguanil 400mg daily


	===Indications by Disease===		===Indications by Disease===
	{{#ask: [[Has DrugName::Atovaquone]] [[Has Population::Pediatric]]		{{#ask: [[Has DrugName::Atovaquone]] [[Has Population::Pediatric]]
	\|?Treats disease=Disease		\|?Treats disease=Disease
	\|?Has Dose=Dose		\|?Has Dose=Dose
	\|?Has Context=Context		\|?Has Context=Context
	\|format=table		\|format=table
	\|limit=50		\|limit=50
	\|mainlabel=-		\|mainlabel=-
	\|headers=show		\|headers=show
	\|sort=Treats disease		\|sort=Treats disease
	}}		}}

Danbot: Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

2026-03-20T01:53:41Z

Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

← Older revision		Revision as of 01:53, 20 March 2026
Line 7:		Line 7:

	==Adult Dosing==		==Adult Dosing==
	*Babesiosis: ~~750mg PO q12h + azithromycin~~		===Indications by Disease===
	*Toxoplasma encephalitis, HIV+: 1500mg daily + leucovorin +/- ~~pyrimethamine~~		{{#ask: [[Has DrugName::Atovaquone]] [[Has Population::Adult]]
	*PCP pneumonia (2nd line): 1500mg daily		\|?Treats disease=Disease
	*Malaria prophylaxis:		\|?Has Dose=Dose
			\|?Has Context=Context
			\|format=table
			\|limit=50
			\|mainlabel=-
			\|headers=show
			\|sort=Treats disease
			}}

	==Pediatric Dosing==		==Pediatric Dosing==
	*Babesiosis: ~~20mg/kg q12h (max 750mg/dose) + azithromycin~~		===Indications by Disease===
	*PCP pneumonia (2nd line)		{{#ask: [[Has DrugName::Atovaquone]] [[Has Population::Pediatric]]
	**>13yo, HIV- : 1500mg daily		\|?Treats disease=Disease
	**Adolescents, HIV+: 1500mg daily +/- leucovorin, +/- pyrimethamine		\|?Has Dose=Dose
	**1-~~3mo, 2-13yo, HIV+: 30 mg/kg PO daily~~		\|?Has Context=Context
	**4-24mo, HIV+: 45mg/kg PO daily		\|format=table
	*Malaria prophylaxis: 250mg + 100mg proguanil daily		\|limit=50
	*Malaria falciparum/vivax treatment: 1000mg + proguanil 400mg daily		\|mainlabel=-
			\|headers=show
			\|sort=Treats disease
			}}

	==Special Populations==		==Special Populations==

ClaireLewis at 20:17, 19 September 2019

2019-09-19T20:17:22Z

← Older revision		Revision as of 20:17, 19 September 2019
Line 56:		Line 56:
	==References==		==References==
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]] [[Category:ID]]

Humanguy: /* Pharmacology */ added metabolism

2017-10-11T20:27:19Z

Pharmacology: added metabolism

← Older revision		Revision as of 20:27, 11 October 2017
Line 44:		Line 44:
	==Pharmacology==		==Pharmacology==
	*Half-life: 2.2-3.2 days		*Half-life: 2.2-3.2 days
	*Metabolism:		*Metabolism: undergoes enterohepatic recirculation
	*Excretion: Fecal		*Excretion: Fecal

Humanguy: added dosage form, dosage strengths, trade name

2017-10-11T20:26:37Z

added dosage form, dosage strengths, trade name

← Older revision		Revision as of 20:26, 11 October 2017
Line 1:		Line 1:
	==Administration==		==Administration==
	*Type: Antimicrobial (active against [[Pneumocystis jirovecii]], [[Babesiosis]], [[Toxoplasmosis]], [[Malaria]])		*Type: Antimicrobial (active against [[Pneumocystis jirovecii]], [[Babesiosis]], [[Toxoplasmosis]], [[Malaria]])
	*Dosage Forms:		*Dosage Forms: tablet, oral suspion
	*Routes of Administration: ~~Oral~~		*Dosage Strengths: tablet: 250mg; oral suspension: 750mg/5mL
	*Common Trade Names:		*Routes of Administration: PO
			*Common Trade Names: Mepron

	==Adult Dosing==		==Adult Dosing==

ClaireLewis: Created page with "==Administration== Type: Antimicrobial (active against Pneumocystis jirovecii, Babesiosis, Toxoplasmosis, Malaria) Dosage Forms: *Routes of Administration: O..."

2016-10-09T22:08:47Z

Created page with "==Administration== *Type: Antimicrobial (active against Pneumocystis jirovecii, Babesiosis, Toxoplasmosis, Malaria) *Dosage Forms: *Routes of Administration: O..."

New page

==Administration==
*Type: Antimicrobial (active against [[Pneumocystis jirovecii]], [[Babesiosis]], [[Toxoplasmosis]], [[Malaria]])
*Dosage Forms:
*Routes of Administration: Oral
*Common Trade Names:

==Adult Dosing==
*Babesiosis: 750mg PO q12h + azithromycin
*Toxoplasma encephalitis, HIV+: 1500mg daily + leucovorin +/- pyrimethamine
*PCP pneumonia (2nd line): 1500mg daily
*Malaria prophylaxis:
==Pediatric Dosing==
*Babesiosis: 20mg/kg q12h (max 750mg/dose) + azithromycin
*PCP pneumonia (2nd line)
**>13yo, HIV- : 1500mg daily
**Adolescents, HIV+: 1500mg daily +/- leucovorin, +/- pyrimethamine
**1-3mo, 2-13yo, HIV+: 30 mg/kg PO daily
**4-24mo, HIV+: 45mg/kg PO daily
*Malaria prophylaxis: 250mg + 100mg proguanil daily
*Malaria falciparum/vivax treatment: 1000mg + proguanil 400mg daily

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Renal dosing: atovaquone/proguanil contraindicated in severe renal failure for malaria prophylaxis, otherwise no adjustment
*Hepatic dosing: no adjustment

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*SJS, erythema multiforme
*Methemoglobinemia
*Hepatitis, liver failure
===Common===
*Nausea/vomiting, diarrhea
*Rash
*Headache, insomnia
*Fever
*Cough, rhinitis

==Pharmacology==
*Half-life: 2.2-3.2 days
*Metabolism:
*Excretion: Fecal

==Mechanism of Action==
*Unclear mechanism; structurally similar to ubiquonone, which inhibits cytochromal electron transport in Plasmodia species

==Comments==

==See Also==

==References==
<references/>
[[Category:Pharmacology]]