Antipsychotic toxicity - Revision history

Danbot: Add MedicationDose entries for magnesium sulfate, diphenhydramine, benztropine

2026-03-20T21:17:39Z

Add MedicationDose entries for magnesium sulfate, diphenhydramine, benztropine

@@ Line 55: / Line 55: @@
 **No orthostatic hypotension
 **Normal QT interval
 ==See Also==

Elcatracho: /* See Also */

2021-03-07T04:05:59Z

Elcatracho: /* See Also */

2021-03-07T04:04:22Z

Neil.m.young: Text replacement - "Alpha" to "α"

2017-07-24T01:13:13Z

Text replacement - "Alpha" to "α"

← Older revision		Revision as of 01:13, 24 July 2017
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	*Toxicity results in blockade of some or all of the following receptors:		*Toxicity results in blockade of some or all of the following receptors:
	**Dopamine - extrapyramidal symptoms		**Dopamine - extrapyramidal symptoms
	**~~Alpha~~-1 - orthostatic hypotension, reflex tachycardia		**α-1 - orthostatic hypotension, reflex tachycardia
	**Muscarinic - anticholinergic symptoms		**Muscarinic - anticholinergic symptoms
	**Histamine - sedation		**Histamine - sedation

Mholtz: Text replacement - "OR" to "'''OR'''"

2017-05-31T01:23:37Z

Text replacement - "OR" to "'''OR'''"

← Older revision		Revision as of 01:23, 31 May 2017
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	===Extrapyramidal===		===Extrapyramidal===
	*[[Diphenhydramine]] 25-50mg IV/IM OR [[benztropine]] 1-2mg IV/IM		*[[Diphenhydramine]] 25-50mg IV/IM '''OR''' [[benztropine]] 1-2mg IV/IM
	*Oral therapy with either of above meds should be continued for 2 weeks		*Oral therapy with either of above meds should be continued for 2 weeks

Rossdonaldson1: Text replacement - "Seizure " to "Seizure "

2016-09-25T20:55:34Z

Text replacement - "*Seizure " to "*Seizure "

← Older revision		Revision as of 20:55, 25 September 2016
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	*CNS		*CNS
	**Lethargy, ataxia, dyarthria, confusion, coma		**Lethargy, ataxia, dyarthria, confusion, coma
	**Seizure (1%)		**[[Seizure]] (1%)
	*Anticholinergic Effects		*Anticholinergic Effects
	**Tachycardia, dry mucous membranes, dry skin, decreased bowel sounds, delirium		**Tachycardia, dry mucous membranes, dry skin, decreased bowel sounds, delirium

ClaireLewis: /* Clinical Features */

2016-09-25T16:44:15Z

Clinical Features

← Older revision		Revision as of 16:44, 25 September 2016
Line 9:		Line 9:
	==Clinical Features==		==Clinical Features==
	[[File:Atypical Antipsychotic Toxicity.png\|thumb\|Evaluation of SGA (Second Generation Antipsychotic) Toxicity]]		[[File:Atypical Antipsychotic Toxicity.png\|thumb\|Evaluation of SGA (Second Generation Antipsychotic) Toxicity]]
	*[[Extrapyramidal ~~symptoms~~]]		*[[Extrapyramidal reaction\|Extrapyramidal]]
	**Acute [[dystonic reaction]]		**Acute [[dystonic reaction]]
	***Tongue protrusion, facial grimacing, trismus, oculogyric crisis		***Tongue protrusion, facial grimacing, trismus, oculogyric crisis

ClaireLewis: /* See Also */

2016-09-25T16:43:14Z

ClaireLewis: /* Clinical Features */

2016-09-25T16:42:50Z

Clinical Features

← Older revision		Revision as of 16:42, 25 September 2016
Line 9:		Line 9:
	==Clinical Features==		==Clinical Features==
	[[File:Atypical Antipsychotic Toxicity.png\|thumb\|Evaluation of SGA (Second Generation Antipsychotic) Toxicity]]		[[File:Atypical Antipsychotic Toxicity.png\|thumb\|Evaluation of SGA (Second Generation Antipsychotic) Toxicity]]
	*Extrapyramidal		*[[Extrapyramidal symptoms]]
	**Acute ~~dystonia~~		**Acute [[dystonic reaction]]
	***Tongue protrusion, facial grimacing, trismus, oculogyric crisis		***Tongue protrusion, facial grimacing, trismus, oculogyric crisis
	**Akathisia		**Akathisia
Line 20:		Line 20:
	*[[ECG]] changes		*[[ECG]] changes
	**Sinus tachycardia		**Sinus tachycardia
	**QT prolongation		**[[QT prolongation]]

	==Differential Diagnosis==		==Differential Diagnosis==

Rossdonaldson1: Text replacement - "ECG" to "ECG"

2016-09-09T12:16:09Z

Text replacement - "*ECG" to "*ECG"

← Older revision		Revision as of 12:16, 9 September 2016
Line 18:		Line 18:
	*Anticholinergic Effects		*Anticholinergic Effects
	**Tachycardia, dry mucous membranes, dry skin, decreased bowel sounds, delirium		**Tachycardia, dry mucous membranes, dry skin, decreased bowel sounds, delirium
	*ECG changes		*[[ECG]] changes
	**Sinus tachycardia		**Sinus tachycardia
	**QT prolongation		**QT prolongation
Line 28:		Line 28:
	===Workup===		===Workup===
	*POC Glucose		*POC Glucose
	*ECG (QT interval)		*[[ECG]] (QT interval)
	*Co-ingestions: serum acetaminophen, salicylate, EtOH level, other known drug levels		*Co-ingestions: serum acetaminophen, salicylate, EtOH level, other known drug levels
	*Urine toxicology screen		*Urine toxicology screen

← Older revision		Revision as of 04:05, 7 March 2021
Line 57:		Line 57:

	==See Also==		==See Also==
			*[[Antipsychotics]]
	*[[Toxicology (main)]]		*[[Toxicology (main)]]
	*[[Neuroleptic Malignant Syndrome (NMS)]]		*[[Neuroleptic Malignant Syndrome (NMS)]]

← Older revision		Revision as of 04:04, 7 March 2021
Line 57:		Line 57:

	==See Also==		==See Also==
			*[[Toxicology (main)]]
	*[[Neuroleptic Malignant Syndrome (NMS)]]		*[[Neuroleptic Malignant Syndrome (NMS)]]
	*[[Tardive_dyskinesia\|Tardive dyskinesia]]		*[[Tardive_dyskinesia\|Tardive dyskinesia]]

← Older revision		Revision as of 16:43, 25 September 2016
Line 61:		Line 61:
	*[[Beta-Blocker Toxicity]]		*[[Beta-Blocker Toxicity]]
	*[[Calcium Channel Blocker Toxicity]]		*[[Calcium Channel Blocker Toxicity]]
			*[[Extrapyramidal reaction]]

	==External Links==		==External Links==

Antipsychotic toxicity - Revision history

Danbot: Add MedicationDose entries for magnesium sulfate, diphenhydramine, benztropine

Elcatracho: /* See Also */

Elcatracho: /* See Also */

Neil.m.young: Text replacement - "Alpha" to "α"

Mholtz: Text replacement - "OR" to "'''OR'''"

Rossdonaldson1: Text replacement - "*Seizure " to "*Seizure "

ClaireLewis: /* Clinical Features */

ClaireLewis: /* See Also */

ClaireLewis: /* Clinical Features */

Rossdonaldson1: Text replacement - "*ECG" to "*ECG"

Rossdonaldson1: Text replacement - "Seizure " to "Seizure "

Rossdonaldson1: Text replacement - "ECG" to "ECG"