Andexanet alfa - Revision history

Elcatracho: /* Serious */

2021-02-25T13:40:51Z

Serious

← Older revision		Revision as of 13:40, 25 February 2021
Line 40:		Line 40:
	===Serious===		===Serious===
	*Arterial and venous thromboembolism		*Arterial and venous thromboembolism
	**DVT (6%)		**[[DVT]] (6%)
	**Ischemic stroke (5%)		**[[Ischemic stroke]] (5%)
	**Myocardial infarction (3%)		**[[Myocardial infarction]] (3%)
	**Pulmonary embolism (3%)		**[[Pulmonary embolism]] (3%)
	*Acute Respiratory failure (1%)		*Acute Respiratory failure (1%)
	*Cardiac arrest		*[[Cardiac arrest]]
	*Sudden death		*Sudden death

Mrosen5506: /* See Also */

2018-08-15T20:10:28Z

Mrosen5506: /* Determined by last dose, type of factor Xa inhibitor, and dose of inhibitor */

2018-08-15T20:09:31Z

Determined by last dose, type of factor Xa inhibitor, and dose of inhibitor

← Older revision		Revision as of 20:09, 15 August 2018
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	**Low dose		**Low dose
	*Last dose <8 hours or unknown		*Last dose <8 hours or unknown
	**Apixaban		**[[Apixaban]]
	***<5 mg: Low dose		***<5 mg: Low dose
	***>5 mg/unknown: High dose		***>5 mg/unknown: High dose
	**Rivaroxaban		**[[Rivaroxaban]]
	***<10 mg: Low dose		***<10 mg: Low dose
	***>10 mg/unknown: High dose		***>10 mg/unknown: High dose

Mrosen5506: Created page with "==Administration== Type: factor Xa inhibitor reversal, antidote Dosage Forms: solution reconstituted, 100 mg per vial Routes of Administration: IV Common Trade Names: Ande..."

2018-08-11T19:43:52Z

Created page with "==Administration== *Type: factor Xa inhibitor reversal, antidote *Dosage Forms: solution reconstituted, 100 mg per vial *Routes of Administration: IV *Common Trade Names: Ande..."

New page

==Administration==
*Type: factor Xa inhibitor reversal, antidote
*Dosage Forms: solution reconstituted, 100 mg per vial
*Routes of Administration: IV
*Common Trade Names: Andexxa

==Adult Dosing==
===Determined by last dose, type of factor Xa inhibitor, and dose of inhibitor===
*Last dose >8 hours ago
**Low dose
*Last dose <8 hours or unknown
**Apixaban
***<5 mg: Low dose
***>5 mg/unknown: High dose
**Rivaroxaban
***<10 mg: Low dose
***>10 mg/unknown: High dose

===Low Dose===
'''400''' mg IV bolus at rate of ~30 mg/minute, followed 2 minutes later by '''4''' mg/minute for up to 120 minutes
===High Dose===
'''800''' mg IV bolus at rate of ~30 mg/minute, followed 2 minutes later by '''8''' mg/minute for up to 120 minutes

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*not known

===Lactation risk===
*not known

===Renal Dosing===
*None
===Hepatic Dosing===
*None

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Arterial and venous thromboembolism
**DVT (6%)
**Ischemic stroke (5%)
**Myocardial infarction (3%)
**Pulmonary embolism (3%)
*Acute Respiratory failure (1%)
*Cardiac arrest
*Sudden death

===Common===
*Infusion site reaction
*UTI (5%)
*Pneumonia (5%)

==Pharmacology==
*Half-life: 5 to 7 hours

==Mechanism of Action==
*Binds and sequesters factor Xa inhibitors
*Inhibits the activity of the Tissue Factor Pathway Inhibitor (TFPI), increasing tissue factor-initiated thrombin generation

==Comments==
*FDA approved in May 2018, limited availability June 2018 with broader commercial launch in early 2019
*Cost, $3,300 per 100 mg vial

==See Also==
*[[Anticoagulant reversal for life-threatening bleeds]]
*[[Rivaroxaban reversal]]
*[[Apixaban]]

==References==
*Lu, G., DeGuzman, F. R., Hollenbach, S. J., Karbarz, M. J., Abe, K., Lee, G., … Sinha, U. (2013). A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nature Medicine, 19(4), 446–451.
*Andexxa (andexanet alfa) [prescribing information]. South San Francisco, CA: Portola Pharmaceuticals, Inc; May 2018
<references/>

[[Category:Pharmacology]]

← Older revision		Revision as of 20:10, 15 August 2018
Line 65:		Line 65:

	==See Also==		==See Also==
			*[[Apixaban]]
			*[[Rivaroxaban]]
	*[[Anticoagulant reversal for life-threatening bleeds]]		*[[Anticoagulant reversal for life-threatening bleeds]]
	*[[Rivaroxaban reversal]]		*[[Rivaroxaban reversal]]
	*[[Apixaban]]

	==References==		==References==

Andexanet alfa - Revision history

Elcatracho: /* Serious */

Mrosen5506: /* See Also */

Mrosen5506: /* Determined by last dose, type of factor Xa inhibitor, and dose of inhibitor */

Mrosen5506: Created page with "==Administration== *Type: factor Xa inhibitor reversal, antidote *Dosage Forms: solution reconstituted, 100 mg per vial *Routes of Administration: IV *Common Trade Names: Ande..."

Mrosen5506: Created page with "==Administration== Type: factor Xa inhibitor reversal, antidote Dosage Forms: solution reconstituted, 100 mg per vial Routes of Administration: IV Common Trade Names: Ande..."