https://wikem.org/w/index.php?action=history&feed=atom&title=Acetaminophen_level 2026-04-17T18:55:50Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Acetaminophen_level&diff=388775&oldid=prev 2026-03-22T06:58:13Z

<p>Create lab page for Acetaminophen level with EM-focused content and references</p> <p><b>New page</b></p><div>==Background==<br /> *Serum acetaminophen (APAP) concentration; essential in any intentional ingestion or unknown overdose<br /> <br /> ==Normal Values==<br /> *Therapeutic: 10-20 mcg/mL<br /> *Toxicity assessment: plot on Rumack-Matthew nomogram at 4 hours post-ingestion<br /> <br /> ==Interpretation==<br /> *Draw level at 4 hours post-ingestion (or immediately if &gt;4 hours); use Rumack-Matthew nomogram to determine need for N-acetylcysteine (NAC)<br /> *Treatment line: 150 mcg/mL at 4 hours (some use lower 100 mcg/mL line for added safety)<br /> *Check APAP level on all intentional ingestions regardless of reported substance (co-ingestion is common)<br /> *Undetectable level at &gt;4 hours after acute ingestion essentially rules out toxic ingestion<br /> *Chronic/repeated supratherapeutic ingestion: nomogram does not apply; treat based on level, AST/ALT, and clinical picture&lt;ref&gt;Heard KJ. Acetylcysteine for acetaminophen poisoning. N Engl J Med. 2008; 359(3):285-292. PMID 18635433.&lt;/ref&gt;<br /> <br /> ==See Also==<br /> *[[Acetaminophen toxicity]]<br /> *[[N-acetylcysteine]]<br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Labs]]</div>

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