View source for Cefuzonam

==General==
*Type: [[Is Generation::2nd generation]] [[Is DrugClass::Cephalosporin]]
*Dosage Forms: powder for injection
*Dosage Strengths: 250mg, 500mg, 1g
*Routes of Administration: IV, IM
*Common Trade Names: Cosmosin

==Adult Dosing==
===General===
*1-2g/day IM/IV divided q12h

===Severe Infections===
*Up to 4g/day IM/IV divided q12h

==Pediatric Dosing==
===General===
*40-80mg/kg/day IM/IV divided q6-8h
*Max: 150mg/kg/day for severe infections (do not exceed 4g/day)

==Special Populations==
*Pregnancy: Safety not established (Use only if clearly needed)
*Lactation: Excreted in breast milk (Caution advised)
*Renal
**Adult
***CrCl 30-50: 500mg q12h
***CrCl 10-29: 500mg q24h
***CrCl <10: 500mg q48h
***Hemodialysis: Give dose after dialysis
**Pediatric
***Renal impairment: Reduce dose or extend interval
*Hepatic
**No specific adjustment defined

==Contraindications==
*Allergy to class/drug
*Previous shock to Cefuzonam

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]] / Shock
*[[Stevens-Johnson Syndrome]]
*Toxic Epidermal Necrolysis
*[[Pancytopenia]] / Agranulocytosis
*[[Interstitial Pneumonia]] (PIE syndrome)
*[[Pseudomembranous colitis]] ([[Clostridium difficile]])
*Acute Renal Failure

===Common===
*[[Diarrhea]]
*[[Rash]]
*[[Nausea and Vomiting]]
*Elevated LFTs (AST/ALT)
*Eosinophilia
*Injection site pain/phlebitis

==Pharmacology==
*Half-life: ~1 hour (extended in renal failure)
*Metabolism: Not significantly metabolized
*Excretion: Urine (largely unchanged)
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis

==[[Antibiotic Sensitivities]]==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||'''S'''
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||'''S'''
|-
| ||[[N. meningitidis]]||'''S'''
|-
| ||[[Moraxella catarrhalis]]||'''S'''
|-
| ||[[H. influenzae]]||'''S'''
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||I
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||I
|-
| ||Serratia marcescens||R
|-
| ||[[Salmonella]] sp||'''S'''
|-
| ||[[Shigella]] sp||'''S'''
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||'''S'''
|-
| ||[[Providencia sp.]]||'''S'''
|-
| ||[[Morganella sp.]]||'''S'''
|-
| ||[[Citrobacter freundii]]||I
|-
| ||[[Citrobacter diversus]]||I
|-
| ||[[Citrobacter sp.]]||I
|-
| ||[[Aeromonas sp]]||I
|-
| ||[[Acinetobacter sp.]]||R
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||I
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||'''S'''
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||X1
|-
| ||[[Mycoplasm pneumoniae]]||X1
|-
| ||[[Rickettsia sp]]||X1
|-
| ||[[Mycobacterium avium]]||X1
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||R
|-
| ||[[Prevotella melaninogenica]]||I
|-
| ||[[Clostridium difficile]]||R
|-
| ||[[Clostridium (not difficile)]]||I
|-
| ||[[Fusobacterium necrophorum]]||I
|-
| ||[[Peptostreptococcus sp.]]||'''S'''
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]